+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Effects of a luteolytic dose of oestradiol benzoate on uterine oxytocin receptor concentrations, phosphoinositide turnover and prostaglandin F-2 alpha secretion in sheep



Effects of a luteolytic dose of oestradiol benzoate on uterine oxytocin receptor concentrations, phosphoinositide turnover and prostaglandin F-2 alpha secretion in sheep



Journal of Reproduction and Fertility 79(2): 457-467



Administration of oestradiol-17.beta. benzoate on Days 9 and 10 of the oestrous cycle resulted in episodic secretion of PGF-2.alpha. (as indicated by elevated circulating concentrations of 13, 14-dihydro-15-ketoprostaglandin F-2.alpha.) and a decline in circulating progesterone. Release of PGF-2.alpha. began 35 .+-. 3 h after first injection of oestrogen and progesterone concentrations declined from 42 .+-. 3 h. Secretions of oxytocin, which was first observed 26 .+-. 3 h after oestrogen treatment, preceded secretion of PGF-2.alpha.; 69% of pulses of oxytocin coincided with episodes of PGF-2.alpha. secretion. Uterine oxytocin receptor concentrations were raised in ewes treated with oestrogen, increases occurring in caruncular endometrium and myometrium by 12 h after treatment and in intercaruncular endometrium by 24 h. Raised receptor concentrations were followed at 24 h by increases in the incorporation of [3H]inositol into phosphatidylinositol and in the hydrolysis of labelled tissue phosphoinositides in response to oxytocin in slices of caruncular endometrium incubated in vitro. The following sequence of events is therefore suggested to occur at oestrogen-induced luteolysis: (a) induction of the oxytocin receptor; (b) increased turnover of phosphoinositides; (c) onset of episodic secretion of PGF-2.alpha.; and (d) functional luteolysis.

(PDF emailed within 1 workday: $29.90)

Accession: 001579575

Download citation: RISBibTeXText

PMID: 3033233


Related references

Effects of a luteolytic dose of oestradiol benzoate on uterine oxytocin receptor concentrations, phosphoinositide turnover and prostaglandin F-2 secretion in sheep. Journal Reprod Fertil 79(2): 457-467, 1987

Direct effects of oestradiol-17 beta and prostaglandin E-2 in protecting pig corpora lutea from a luteolytic dose of prostaglandin F-2 alpha. Journal of Reproduction and Fertility 93(1): 203-209, 1991

Proteins secreted by the sheep conceptus suppress induction of uterine prostaglandin F-2 alpha release by oestradiol and oxytocin. Journal of Reproduction and Fertility 76(1): 425-433, 1986

Relationships among endometrial oxytocin receptors, oxytocin-stimulated phosphoinositide hydrolysis and prostaglandin F2 alpha secretion in vitro, and plasma concentrations of ovarian steroids before and during corpus luteum regression in cyclic heifers. Biology of Reproduction 48(4): 874-882, 1993

Oxytocin (OT) action in uterine tissues of cyclic and early pregnant gilts: OT receptors concentration, prostaglandin F(2)alpha secretion, and phosphoinositide hydrolysis. Animal Reproduction Science 88(3-4): 325-339, 2005

Direct effects of oestradiol-17b and prostaglandin E-2 in protecting pig corpora lutea from a luteolytic dose of prostaglandin F-2a. Journal of Reproduction and Fertility 93: 3-9, 1991

Direct effects of oestradiol-17 and prostaglandin E-2 in protecting pig corpora lutea from a luteolytic dose of prostaglandin F-2. Journal Reprod Fertil 93(1): 203-209, 1991

Regulation of oxytocin, oestradiol and progesterone receptor concentrations in different uterine regions by oestradiol, progesterone and oxytocin in ovariectomized ewes. Journal of Endocrinology 151(3): 375-393, 1996

Oxytocin- and aluminium fluoride-induced phospholipase C activity and prostaglandin F2 alpha secretion during the ovine luteolytic period. Journal of Reproduction and Fertility 112(2): 225-231, 1998

Relationship between uterine secretion of prostaglandin F2 alpha induced by oxytocin and endogenous concentrations of estradiol and progesterone at three stages of the bovine estrous cycle. Journal of Animal Science 67(9): 2347-2353, 1989

Oxytocin and the timing of parturition. Influence of oxytocin receptor gene expression, oxytocin secretion, and oxytocin-induced prostaglandin F2 alpha and E2 release. Advances in Experimental Medicine and Biology 395: 405-420, 1995

Proteins secreted by the sheep conceptus suppress induction of uterine prostaglandin F-2 release by oestradiol and oxytocin. Journal Reprod Fertil 76(1): 425-433, 1986

Effects of progesterone withdrawal on uterine secretion of prostaglandin F2 alpha in response to oxytocin in ewes. Reproduction, Fertility, and Development 9(2): 255-262, 1997

Modulation of oxytocin and prostaglandin F2 alpha secretion by oestradiol during luteolysis in ewes. Acta Veterinaria et Zootechnica Sinica 24(3): 224-229, 1993

Effects of oxytocin oxy pregnancy and ovine trophoblast protein 1 otp 1 on prostaglandin f2 alpha pgf secretion and phosphatidylinositol pi turnover by endometrium in vitro. Biology of Reproduction 38(SUPPL 1): 135, 1988