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Effects of carbohydrates on insulin release from the isolated islets



Effects of carbohydrates on insulin release from the isolated islets



Tohoku Journal of Experimental Medicine 149(2): 183-189



Effects of monosaccharides and disaccharides on insulin release from the isolated islets were studied. (1) Insulin release from the isolated islets was 26.2 .mu.U/5 islets/hr in carbohydrate-free medium and increased by the addition of D-glucose or D-mannose, L-Glucose was ineffective by itself but potentiated the insulin release stimulated by D-glucose. Effects of glucuronic and N-acetyl-D-glucosamine on insulin release were similar to those of L-glucose. (2) Among monosaccharides, 2-deoxy-D-ribose, D-galactosamine, L-fucose, N-acetylneuraminic acid and D-ribose decreased insulin release and had no effect on insulin release by D-glucose. (3) D-Galactose and D-fructose also decreased insulin release. However, they potentiated the insulin release when D-glucose was also present. (4) Cellobiose and lactose, which have a .beta.(1-4) linkage to glucose molecule at the reducing end, inhibited insulin release stimulated by D-glucose. On the other hand, sucrose and maltose lacking the .beta.(1-4) linkage, did not inhibit the insulin release stimulated by D-glucose. These results suggest that insulin release from the isolated islets is stimulated by carbohydrates which can be metabolized in B-cells. Non-metabolizable analogues of D-glucose or disaccharides show different effects on glucose transport or glucose metabolism in the B-cells according to their chemical structures.

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Accession: 001580012

Download citation: RISBibTeXText

PMID: 3529502

DOI: 10.1620/tjem.149.183



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