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Effects of catecholaminergic blockade by haloperidol or propranolol at different stages of the oestrous cycle on ovulation and gonadotrophin levels in the rat



Effects of catecholaminergic blockade by haloperidol or propranolol at different stages of the oestrous cycle on ovulation and gonadotrophin levels in the rat



Journal of Endocrinology 113(1): 37-44



Rats with a 4-day oestrous cycle were injected with 2.5 mg haloperidol (a dopaminergic blocker)/kg body weight or with 2.0 mg propranolol/kg (a beta 1- and beta 2-receptor blocker) at 13.00 h on oestrus, dioestrus-I, dioestrus-II or pro-oestrus. Animals were autopsied on the next expected day of oestrus. Haloperidol blocked ovulation when injected on oestrus, dioestrus-I or pro-oestrus, and was less effective when injected on dioestrus-II.

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Accession: 001580032

Download citation: RISBibTeXText

PMID: 3108438

DOI: 10.1677/joe.0.1130037



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