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Effects of cholinergic stimulation and antagonism on plasma insulin concentration in lean and obese human subjects

Effects of cholinergic stimulation and antagonism on plasma insulin concentration in lean and obese human subjects

Hormone and Metabolic Research 18(12): 821-826

The effect of cholinomimetic stimulation by infusion of edrophonium chloride or muscarinic blockade by infusion of atropine sulphate on insulin and gastric inhibitory polypeptide (GIP) secretion was studied in 13 normal lean persons during eu- and hyperglycaemia. Cholinomimetic stimulation caused a non-significant increase and muscarinic blockade a non-significant suppression of GIP and insulin. No modification of the insulin secretion pattern was observed in either condition during hyperglycaemia. The effect of atropine infusion on fasting plasma insulin and GIP was subsequently studied in 11 obese patients and 10 lean persons. Muscarinic antagonism by atropine caused a transient non-significant suppression of GIP and insulin in lean persons, but a significant sustained suppression of these hormones in obese patients. Insulin and GIP were not suppressed to control values after atropine was given to obese patients. A positive correlation was found between fasting plasma insulin and maximum suppression of insulin attained during the 30 min after administration of atropine. It is concluded that part of the hyperinsulinaemia observed in human obesity is under the control of the parasympathetic nervous system. An abnormal balance between sympathetic inhibitory and parasympathetic stimulatory tones on insulin secretion, as observed in rats with lesions of the ventromedial hypothalamus, might be present in human obesity.

Accession: 001580113

Download citation: RISBibTeXText

PMID: 3546047

DOI: 10.1055/s-2007-1012448

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