EurekaMag.com logo
+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Effects of dose and duration of therapy on gentamicin tissue residues in sheep



Effects of dose and duration of therapy on gentamicin tissue residues in sheep



American Journal of Veterinary Research 47(11): 2373-2379



The effects of different doses and dosage regimens on gentamicin pharmacokinetics and tissue residues were determined. Five groups of 12 sheep each were given gentamicin IM: group I, 2 mg of gentamicin sulfate/kg once; group II, 6 mg/kg once; group III, 18 mg/kg once; group IV, 6 mg/kg every 24 hours for 3 doses; and group V, 2 mg/kg every 8 hours for 9 doses. Serum concentrations were determined serially until sheep were killed and necropsied. Three sheep from each group were killed at 1, 4, 8, and 12 days after the last dose was administered. Renal cortex, renal medulla, liver, spleen, lung, skeletal muscle, and skeletal muscle at the injection site were assayed for gentamicin. An exponential equation was fitted to the serum concentrations, and various pharmacokinetic variables were determined. Serum clearance tended to increase as the single dose increased (P = 0.0588). Steady-state volume of distribution increased as the single dose was increased (P < 0.05). Renal cortex contained the highest concentration of gentamicin which decreased in a biexponential manner. Concentrations in all tissues, except the injection site, were dependent upon the amount of the total dose, not the size of the injected dose (P < 0.05). Concentrations at the injection site were up to 29 .mu.g/g of tissue at 1 day after the last dose was given and were dependent upon the amount of total dose from multiple injections, not on the amount of each injected dose (P < 0.05). These results indicated that tissue residues increased as the total dose gentamicin was increased or as the duration of gentamicin therapy was increased. Furthermore, the injection site contained substantial amounts of gentamicin at 1 day after the last dose was given.

(PDF emailed within 1 workday: $29.90)

Accession: 001580550

Download citation: RISBibTeXText

PMID: 3789497



Related references

Single intravenous and multiple intramuscular dose pharmacokinetics and tissue residue profile of gentamicin in sheep. American Journal of Veterinary Research 46(1): 69-74, 1985

Tissue residues of gentamicin in pigs after oral administration of a gentamicin product via drinking water. 39th Annual Report of the National Veterinary Assay Laboratory, 2002: 33-35, 2002

High-dose, long-duration versus low-dose, short-duration corticotropin therapy for infantile spasms. Journal Of Pediatrics. 124(5 Part 1): 803-806, 1994

Use of tissue-fluid correlations to estimate gentamicin residues in kidney tissue of Holstein steers. Journal of Veterinary Pharmacology and Therapeutics 29(2): 99-106, 2006

Prediction of renal gentamicin residues in sheep using power functions. Federation Proceedings 45(3): 207, 1986

Delayed onset of ototoxic effects of gentamicin in treatment of Menière's disease. Rationale for extremely low dose therapy. Acta Oto-Laryngologica 111(4): 671-676, 1991

A crossing in therapy for hepatitis C virus genotype 2 or 3: increasing ribavirin dose with shortened duration or reducing ribavirin dose with standard duration. Hepatology 49(4): 1395-6; Author Reply 1396, 2009

Dose-dependent pharmacokinetics of gentamicin in sheep. American Journal of Veterinary Research 47(4): 789-794, 1986

Superiority of the power function over exponential functions for prediction of renal gentamicin residues in sheep. Journal of Veterinary Pharmacology and Therapeutics 9(3): 341-346, 1986

Interrelationship of dose and duration of amiodarone therapy on electrophysiologic and antiarrhythmic effects. Clinical Research 32(4): 780A, 1984

Hormonal control of fertility in sheep. 4. Effect of the duration of FGA treatment and of PMSG dose on the reproductive performance of Altamura sheep in the non-breeding season. Annali della Facolta di Agraria, Universita di Bari80 1983; 31: 165-173, 1979

Optimizing dose and fractionation for stereotactic body radiation therapy. Normal tissue and tumor control effects with large dose per fraction. Frontiers of Radiation Therapy and Oncology 40: 352-365, 2007

Gentamicin in newborn calves: pharmacokinetics, tissue distribution, residues and tolerance. Archivio Veterinario Italiano 29(3/4): 64-68, 1978

Ototoxic effects of single-dose versus 19-day daily-dose gentamicin. Journal of Otolaryngology - Head & Neck Surgery 37(5): 664-667, 2009

Nutritional manipulation of fetal adipose tissue deposition and uncoupling protein 1 messenger RNA abundance in the sheep: differential effects of timing and duration. Biology of Reproduction 71(1): 359-365, 2004