EurekaMag.com logo
+ Site Statistics
References:
54,215,046
Abstracts:
30,230,908
PMIDs:
28,215,208
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Effects of feline leukemia virus infection on neutrophil chemotaxis in vitro



Effects of feline leukemia virus infection on neutrophil chemotaxis in vitro



American Journal of Veterinary Research 48(1): 76-80



A procedure for measuring in vitro feline neutrophil chemotaxis was developed, using a modified Boyden chamber apparatus and 3-microns-pore polycarbonate filters. A pooled feline serum sample was used as the chemoattractant. Chemotaxis was evaluated in 5 groups of cats: group 1-specific-pathogen-free cats that had not been exposed to feline leukemia virus (FeLV); group 2-previremic, FeLV-infected, specific-pathogen-free cats; group 3-FeLV-viremic, subclinically affected cats; group 4-FeLV-viremic, clinically affected cats; and group 5-sick cats that were not infected with FeLV. Neutrophils from the viremic, clinically affected cats had significantly lower (P less than 0.025) chemotactic responses than did those from subclinically affected, viremic cats. Conversely, neutrophils from cats that were ill due to causes other than FeLV had the highest mean chemotactic values. Among the viremic, subclinically affected cats, a linear relationship was found between age and chemotaxis, indicating that impairment of neutrophil function may be greater in younger viremic cats. However, FeLV-infected cats can not be identified on the basis of neutrophil chemotaxis.

(PDF emailed within 1 workday: $29.90)

Accession: 001580828

Download citation: RISBibTeXText

PMID: 3030165



Related references

Tumor necrosis factor alpha levels in cats experimentally infected with feline immunodeficiency virus: effects of immunization and feline leukemia virus infection. Veterinary Immunology and Immunopathology 35(1-2): 61-69, 1992

Interspecies infection by feline leukemia virus: serial cell-free transmission in dogs of malignant lymphomas induced by feline leukemia virus. Bibliotheca Haematologica 39: 102-112, 1973

Determinants of susceptibility and resistance to feline leukemia virus infection. II. Susceptibility of feline lymphocytes to productive feline leukemia virus infection. Journal of the National Cancer Institute 67(4): 899-910, 1981

An in vitro focus-induction assay for xenotropic murine leukemia virus, feline leukemia virus C, and the feline--primate viruses RD-114/CCC/M-7. Virology 67(1): 288-291, 1975

Association between endogenous feline leukemia virus loads and exogenous feline leukemia virus infection in domestic cats. Virus Research 135(1): 136-143, 2008

Vaccination of cats against infection with feline leukemia virus (FeLV): first recombinant vaccine and the effect of a pre-existing infection with feline immunodeficiency virus (FIV). Schweizer Archiv für Tierheilkunde 136(10): 340-351, 1994

Feline leukemia virus infection as a potentiating cofactor for the primary and secondary stages of experimentally induced feline immunodeficiency virus infection. Journal of Virology 64(2): 598-606, 1990

Therapeutic effects of recombinant feline interferon-omega on feline leukemia virus -infected and FeLV/feline immunodeficiency virus -coinfected symptomatic cats. Journal of Veterinary Internal Medicine 18(4): 477-482, July, 2004

Feline leukemia virus infection in a captive cheetah and the clinical and antibody response of six captive cheetahs to vaccination with a subunit feline leukemia virus vaccine. Journal of the American Veterinary Medical Association 189(9): 1197-1199, 1986

Infection of feline embryo adherent cells with feline leukemia virus: feline oncornavirus-associated cell membrane antigen expression and morphologic transformation. Journal of the National Cancer Institute 66(1): 89-96, 1981

Evaluation of the association of Bartonella species, feline herpesvirus 1, feline calicivirus, feline leukemia virus and feline immunodeficiency virus with chronic feline gingivostomatitis. Journal of Feline Medicine and Surgery 10(1): 66-72, 2007

Seroprevalence of feline leukemia virus, feline immunodeficiency virus and heartworm infection among owned cats in tropical Mexico. Journal of Feline Medicine and Surgery 16(6): 460-464, 2015

Granulocyte colony-stimulating factor enhances neutrophil chemotaxis and attenuates alcohol-induced suppression of neutrophil chemotaxis in vitro. Alcoholism Clinical & Experimental Research 24(5 Supplement): 20A, 2000