EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Effects of food restriction and hyperoxia on rat survival and lung polyamine metabolism



Effects of food restriction and hyperoxia on rat survival and lung polyamine metabolism



Journal of Applied Physiology 64(5): 2010-2016



We fed Sprague-Dawley rats either freely or by restricting them to 20% of their usual diet for 21 days. In one experiment, we refed half of the food-restricted rats for 12 h, then exposed the three groups to air or 85% O2 for 5 days. The mortalities in 85% O2 were 100, 33, and 0% for the food-restricted, restricted-refed, and freely fed groups, respectively. In air lung polyamine contents and glucose 6-phosphate dehydrogenase and NADP-dependent isocitrate dehydrogenase activities were significantly lower with food restriction. After hyperoxia, lung polyamine and protein contents and enzyme activities were increased in the two surviving groups, but spermine and DNA contents of refed rats did not increase. In a second experiment, we exposed rats to 60% O2 and found that DNA synthesis of food-restricted rats was lower than the freely fed rats in air and remained low after hyperoxia. We conclude that food restriction increases the mortality from 85% O2 and is associated with lower DNA synthesis and polyamine content. We speculate that food-restricted animals may accumulate greater binding injury partly because of a compromised repair process.

(PDF emailed within 1 workday: $29.90)

Accession: 001580934

Download citation: RISBibTeXText

PMID: 3391899



Related references

Effect of food restriction on hyperoxia-induced lung injury in preterm guinea pig. American Journal of Physiology 263(3 Pt 1): L357-L362, 1992

Nutritional restriction and hyperoxia effects on lung development in preterm rabbits. Pediatric Research 53(4 Part 2): 430A, April, 2003

Effects of hypoxia and hyperoxia on lung prostaglandin E1 metabolism. American Journal of the Medical Sciences 313(3): 147-152, 1997

Incomplete response of polyamine metabolism in mouse lungs exposed to hyperoxia. American Review of Respiratory Disease 131(4 SUPPL): A378, 1985

Polyamine analogue CPENSpm inhibits proliferation of human lung cancer cells by interfering polyamine metabolism. Zhongguo Yaolixue Tongbao 24(1): 132-135, 2008

Modification by hyperoxia of chlorphentermine- or phentermine- induced effects on newborn rat lung morphology and metabolism. Drug and Chemical Toxicology 4(2): 123-132, 1981

Differential response of developing human fetal lung explants to hyperoxia and the effects of dexamethasone on hyperoxia-exposed lungs. Zhongguo Dang Dai Er Ke Za Zhi 8(2): 105-108, 2006

Effects of food restriction on growth, body composition and gene expression related in regulation of lipid metabolism and food intake in grass carp. Aquaculture 469: 28-35, 2017

Effects of food restriction on whole body metabolism. Aging 3(4): 386-388, 1991

Effects of a polyamine-enriched diet on growth, development and polyamine metabolism in rats. Gastroenterology 120(5 Supplement 1): A 302, April, 2001

Effects of polyamine-enriched diets on growth, development and polyamine metabolism of rats. European Journal of Clinical Investigation 29(SUPPL 1): 21, April, 1999

Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues. Microbiology 150(Pt 5): 1215-1224, 2004

Survival, lung injury, and lung protein nitration in heterozygous MnSOD knockout mice in hyperoxia. Experimental Lung Research 25(7): 631-646, 1999

The effects of food restriction in man on hepatic metabolism of acetaminophen. Clinical Nutrition 20(2): 145-150, 2001

Effects of Ri TL-DNA from Agrobacterium rhizogenes and the inhibitors of polyamine synthesis on growth, floral development, sexual organogenesis and polyamine metabolism in tobacco. Plant Science Limerick 80(1-2): 131-144, 1991