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Incidence of diarrhoea and of rotavirus- and coronavirus-shedding in calves, whose dams had been vaccinated with an experimental oil-adjuvanted vaccine containing bovine rotavirus and bovine coronavirus



Incidence of diarrhoea and of rotavirus- and coronavirus-shedding in calves, whose dams had been vaccinated with an experimental oil-adjuvanted vaccine containing bovine rotavirus and bovine coronavirus



Journal of Veterinary Medicine, B Infectious Diseases, Immunology, Food Hygiene, Veterinary Public Health 35(3): 186-196



Dam-vaccination with an experimental oil-adjuvanted vaccine containing inactivated bovine rotavirus and coronavirus was practised. Fifty pregnant cows of a consistently field-infected Brown Swiss breeding herd were partly vaccinated, partly left as unvaccinated controls during one breeding season. The antibody titres of blood sera of all cows were determined previous to and following vaccination, as well as following parturition. Also, antibodies were determined in first-day colostrum and later milk of cows, as well as in sera of calves when 4 to 6 days old. Calves were exclusively fed colostrum and milk of their proper dams during their first 2 weeks of life. In the same period 35 calves were examined for development of diarrhoea and excretion of rotavirus and/or coronavirus when kept under natural holding conditions. Sixteen other calves were perorally test-infected with virulent rotavirus, 3 days later additionally with virulent coronavirus, and thereafter controlled in the same manner. The experimental vaccine boosted preexisting antibody titres (present in all cows as a result of former field infections by these 2 viruses), but merely at an insufficient degree. Geometric mean titres in colostrum of vaccinated cows were less boosted than expected from the literature and titres of milk were remarkably low. Nevertheless, immediately following parturition even severe experimental test-infections were kept under control by colostral antibodies. So were the less severe natural field infections for the first week of life of calves. In their second week of life, however, lactogenic immunity was of insufficient potency to consistently protect calves kept under natural conditions against the degree of rotavirus and coronavirus exposure actually present on these premises.

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Accession: 001614895

Download citation: RISBibTeXText

PMID: 2844041

DOI: 10.1111/j.1439-0450.1988.tb00486.x


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