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Influence of severe protein deficiency and of severe food intake restriction on serum levels of thyroid hormones in the weanling mouse



Influence of severe protein deficiency and of severe food intake restriction on serum levels of thyroid hormones in the weanling mouse



Nutrition research 7(1): 101-107



Serum levels of thyroid hormones viz. total and free thyroxine (T4) and triiodothyronine (T3) were determined in protocols representing the two most common rodent models of severe protein-energy malnutrition (PEM). In one experiment male and female CBA/J mice were fed from 23 to 37 days of age either a nutritionally adequate diet in restricted quantities or an isocaloric low-protein formulation ad libitum. An ad libitum-fed control group was also included. In a second experiment a control and a low-protein group were fed from 23 to 63 days of age. Severe malnutrition was indicated by weight loss, by mortalities and, in the longer-term study, by the development of fluid accumulation. Mice fed the low-protein diet for 14 days exhibited serum total and free T3 levels which did not differ from control values, while total T4 levels were high. By contrast, the food intake restriction protocol (14 days) and the low-protein diet fed for 40 days each mimicked the human response to severe PEM insofar as serum total and free T3 levels were reduced, in the present experiments, to values between 12% and 54% of control levels. The results show that both the food intake restriction type and (contrary to existing evidence) the low-protein type of rodent protocol for experimental PEM can be used to model the human thyroid hormone response to severe malnutrition.

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Accession: 001618178

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DOI: 10.1016/S0271-5317(87)80195-1



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