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Interspecific melanocyte chimaeras made by introducing rat cells into postimplantation mouse embryos in utero

Interspecific melanocyte chimaeras made by introducing rat cells into postimplantation mouse embryos in utero

Developmental Biology 129(2): 586-589

Dissociated cells of whole midgestation rat embryos were injected into implanted albino mouse embryos on Day 8.5 of gestation in utero. This successfully viable interspecific chimaeras which were found to have pigmented hairs. Two of them had many pigmented hair covering a large area of their bodies, including a forelimb and a hindlimb. The fact that some of the introduced rat cells differentiated into functional melanocytes suggests that embryonic cells of both species were able to interact with each other normally and that the foreign cells were kept from maternal immunological assault.

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Accession: 001622213

Download citation: RISBibTeXText

PMID: 3417054

DOI: 10.1016/0012-1606(88)90404-6

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