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Pathogenesis of degenerative joint disease

Pathogenesis of degenerative joint disease

Equine Veterinary Journal 19(1): 15-18

Proteoglycan degradation is central to the development of degenerative joint disease. Proteoglycans may be degraded by lysosomal enzymes from chondrocytes, synoviocytes or leukocytes. Collagen and matrix degradation occurs either by direct damage or due to degrading enzymes released into synovial fluid. Once the pathological sequence has begun it continues in a cyclic manner unless arrested by the ability of chondrocytes to synthesise sufficient matrix components.

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Accession: 001651183

Download citation: RISBibTeXText

PMID: 3319576

DOI: 10.1111/j.2042-3306.1987.tb02569.x

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