+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Pathogenesis of degenerative joint disease



Pathogenesis of degenerative joint disease



Equine Veterinary Journal 19(1): 15-18



Proteoglycan degradation is central to the development of degenerative joint disease. Proteoglycans may be degraded by lysosomal enzymes from chondrocytes, synoviocytes or leukocytes. Collagen and matrix degradation occurs either by direct damage or due to degrading enzymes released into synovial fluid. Once the pathological sequence has begun it continues in a cyclic manner unless arrested by the ability of chondrocytes to synthesise sufficient matrix components.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 001651183

Download citation: RISBibTeXText

PMID: 3319576

DOI: 10.1111/j.2042-3306.1987.tb02569.x


Related references

Pathogenesis of degenerative joint disease in the human temporomandibular joint. Critical Reviews in Oral Biology and Medicine 6(3): 248-277, 1995

Pathogenesis of degenerative temporomandibular joint disease. Journal of Dental Research 72(ABSTR SPEC ISSUE): 344, 1993

Natural history of degenerative joint disease in small laboratory animals. I. Pathologic anatomy of degenerative joint disease in mice. Arch Pathol 62(2): 118-128, 1956

Review of pathogenesis and treatment of degenerative joint disease. Equine Veterinary Journal. Supplement: 3-11, 1988

Degenerative joint disease in dogs. Part II. Characterization and pathogenesis. Zycie Weterynaryjne 80(4): 216-221, 2005

Pathogenesis and pathologic anatomy of degenerative knee joint disease. Przeglad Lekarski 53(3): 178-180, 1996

Pathogenesis of degenerative joint disease produced by in vivo freezing of rabbit articular cartilage. Clinical Orthopaedics and Related Research 1981(155): 259-268, 1981

Early arthrosis in the femoropatellar joint in athletes. A contribution to the pathogenesis of degenerative joint diseases. Archiv für Orthopadische und Unfall-Chirurgie 54: 401-416, 1962

Natural history of degenerative joint disease in small laboratory animals. IV. Degenerative joint disease in the laboratory rat. A.M.A. Archives of Pathology 62(2): 140-142, 1956

Efficacy of glucosamine, chondroitin, and methylsulfonylmethane for spinal degenerative joint disease and degenerative disc disease: a systematic review. Journal of the Canadian Chiropractic Association 55(1): 47-55, 2011

Degenerative joint disease. The treatment of canine degenerative joint disease. Journal of Small Animal Practice 12(2): 101-103, 1971

The trapezium-thumb metacarpal joint: the relationship of joint shape and degenerative joint disease. Hand 15(2): 201-206, 1983

Relationships of hip joint volume ratios with degrees of joint laxity and degenerative disease from youth to maturity in a canine population predisposed to hip joint osteoarthritis. American Journal of Veterinary Research 72(3): 376-383, 2011