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Pharmacokinetics and dosage of chloramphenicol in dogs

Pharmacokinetics and dosage of chloramphenicol in dogs

Pakistan Veterinary Journal 7(3): 95-98

Chloramphenicol plasma concentrations and kinetics of its disappearance from plasma were determined in dogs. Following intravenous administration of a single dose (25 mg/kg), disposition of the drug was described in terms of the exponential expression Cp = Be-.beta.t. Based on chloramphenicol levels in plasma, the elimination half-life was 4.95 .+-. 0.76 h (mean .+-. SEM, n = 7). Total body clearance, which is the sum of all clearance processes, was 83.4 .+-. 28.2 ml/h/kg. The average .+-. SEM value for the apparent volume of distribution (Vd) was 0.52 .+-. 0.09 l/kg. Based on these kinetic parameters and minimum inhibitory concentration of 5 .mu.g/ml, an optimal dosage level for priming was calculated as 19 mg/kg and maintenance dose as 16 mg/kg with a dosing interval of 12 hours. The influence of diseased conditions on the disposition kinetics of chloramphenicol needs examination.

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