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Quantitation of hymenoxon and related sesquiterpene lactones

, : Quantitation of hymenoxon and related sesquiterpene lactones. Journal of Agricultural & Food Chemistry 35(6): 891-895

A rapid and reproducible method for the quantitation of hymenoxon and related sesquiterpene lactones has been developed using reversed-phase HPLC. The methanol extract of a dried and ground plant sample was analyzed on an RP-8 column eluted with methanol-water (1:1, v/v) and monitored at 235 nm. The hymenoxon content of the above ground whole plant of Hymenoxys odorata ranged from 0.21 to 1.27% according to the site, season, and year of collection. Helenalin and mexicanin E were concentrated in the flowering heads (8.95 and 4.66%, respectively) of Helenium microcephalum while tenulin was concentrated in the leaves (6.14%) of Helenium amarum. The detection limit was 25 ng for helenalin and mexicanin E and 75 ng for hymenoxon and tenulin. The recovery rate of hymenoxon was 102.5 .+-. 4.5%.

Accession: 001667115

DOI: 10.1021/jf00078a010

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Related references

Merrill, J.C.; Kim, H.L.; Safe, S.; Murray, C.A.; Hayes, M.A., 1988: Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin. Hymenoxon and helenalin are toxic sesquiterpene lactones present in the toxic range plants Hymenoxys odorata and Helenium microcephalum. Helenalin (25 mg/kg) or hymenoxon (30 mg/kg) administered to immature male ICR mice caused a rapid decrease in...

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