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Reversal of chloroquine resistance in Plasmodium berghei by an inhibitor of microsomal monooxygenase



Reversal of chloroquine resistance in Plasmodium berghei by an inhibitor of microsomal monooxygenase



Meditsinskaya Parazitologiya i Parazitarnye Bolezni (4): 7-10



Mice were infected with a chloroquine resistant strain (ChlR LNK-65) of P. berghei and treated 2 days later with Delagyl (chloroquine) at (i) 250 mg/kg or (ii) 500 mg/kg (intubated into the stomach), or with 250 mg/kg Delagyl plus 20 mg/kg of the microsomal monooxygenase inhibitor Cu (Lys)2 ip (iii); a 4th group was given only Cu (Lys)2 and the 5th group was left untreated.

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Accession: 001676305

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