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Simultaneous determination of chloroquine and metronidazole in human biological fluid by high pressure liquid chromatography

, : Simultaneous determination of chloroquine and metronidazole in human biological fluid by high pressure liquid chromatography. Life Sciences 42(5): 539-546

Chloroquine (CQ) and metronidazole (MZ) were measured in human urine and plasma by HPLC with UV detection. This method was used to analyse plasma levels in 4 African volunteers after an oral dose of 1000 mg CQ and 750 mg MZ, in a European on weekly proplylaxis of 500 mg CQ, and on 50 hospital urine samples. In the Africans peak plasma levels were over and peak time was 1 1/2 - 2 hr. In the European plasma levels ranged from 0.58 to 0.36 .mu.g/ml. Over 80% of the urine samples contained CQ, MZ or both. The assay system was found flexible and economical for the therapeutic monitoring of these two important tropical drugs.

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Accession: 001684478

PMID: 3339947

DOI: 10.1016/0024-3205(88)90095-1

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