EurekaMag.com logo
+ Site Statistics
References:
48,252,460
Abstracts:
22,798,453
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Simultaneous determination of chloroquine and metronidazole in human biological fluid by high pressure liquid chromatography


, : Simultaneous determination of chloroquine and metronidazole in human biological fluid by high pressure liquid chromatography. Life Sciences 42(5): 539-546

Chloroquine (CQ) and metronidazole (MZ) were measured in human urine and plasma by HPLC with UV detection. This method was used to analyse plasma levels in 4 African volunteers after an oral dose of 1000 mg CQ and 750 mg MZ, in a European on weekly proplylaxis of 500 mg CQ, and on 50 hospital urine samples. In the Africans peak plasma levels were over 1.mu.g/ml and peak time was 1 1/2 - 2 hr. In the European plasma levels ranged from 0.58 to 0.36 .mu.g/ml. Over 80% of the urine samples contained CQ, MZ or both. The assay system was found flexible and economical for the therapeutic monitoring of these two important tropical drugs.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 001684478

PMID: 3339947

DOI: 10.1016/0024-3205(88)90095-1

Download PDF Full Text: Simultaneous determination of chloroquine and metronidazole in human biological fluid by high pressure liquid chromatography


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Lacquaniti, F.; Carrozzo, M.; Borghese, N.A., 1993: Time-varying mechanical behavior of multijointed arm in man. 1. The aim of this study was to describe the time-varying changes in the mechanical parameters of a multijointed limb. The parameters we considered are the coefficients of stiffness, viscosity, and inertia. Continuous pseudorandom perturbations we...

Checler, F.; Barelli, H.; Dauch, P.; Dive, V.; Vincent, B.; Vincent, J.P., 1995: Neurolysin: purification and assays. Methods in Enzymology 248: 593-614

Love, G.; Yainshet, A.; Hansard, A., 2000: Australian wood markets in 2010. Australian wood supply is projected to rise significantly in the next ten to fifteen years as hardwood pulpwood production increases from the large areas of short rotation blue gum [Eucalyptus sp.] plantations now being established. At the same ti...

Krutina, V.; Leitmanova, I.F., 2005: Determinants of economic results of the selected agricultural enterprises in mountain and sub-mountain areas in South Bohemia. Using data for the years 1999-2001, this paper examines the characteristics and results of farm enterprises in mountain and sub-mountain areas in South Bohemia, Czech Republic. The structure of farmland, areas under different crops, per hectare yi...

Sporbert, A.; Mertsch, K.; Smolenski, A.; Haseloff, R.F.; Schönfelder, G.; Paul, M.; Ruth, P.; Walter, U.; Blasig, I.E., 1999: Phosphorylation of vasodilator-stimulated phosphoprotein: a consequence of nitric oxide- and cGMP-mediated signal transduction in brain capillary endothelial cells and astrocytes. There is contradictory information on the relevance of nitric oxide (NO) and cGMP for the function of brain capillary endothelial cells (BCEC) forming the blood-brain barrier (BBB). Therefore, NO/cGMP-mediated signal transduction was investigated...

Serrano González, C.; Prats Viñas, J.M., 1998: Unilateral aplasia of the cerebellum in Aicardi's syndrome. A case of unilateral aplasia of the cerebellum in a girl with Aicardi's syndrome is described. Aplasia of an entire hemisphere is one of the least frequent malformations of the cerebellum. Hypoplasia, partial hemispheric defects of the cerebe...

Edmiston, C.E.; Suarez, E.C.; Walker, A.P.; Demeure, M.P.; Frantzides, C.T.; Schulte, W.J.; Wilson, S.D., 1996: Penetration of ciprofloxacin and fleroxacin into biliary tract. Forty patients with chronic cholecystitis or cholelithiasis were prospectively randomized for therapy with either ciprofloxacin or fleroxacin to study the penetration of these two agents into gallbladder tissue, plasma, and bile. Patients received...

Bobrov, A.G.; Kirillina, O.; Ryjenkov, D.A.; Waters, C.M.; Price, P.A.; Fetherston, J.D.; Mack, D.; Goldman, W.E.; Gomelsky, M.; Perry, R.D., 2011: Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis. Cyclic di-GMP (c-di-GMP) is a signalling molecule that governs the transition between planktonic and biofilm states. Previously, we showed that the diguanylate cyclase HmsT and the putative c-di-GMP phosphodiesterase HmsP inversely regulate biofil...

Migirov, L.; Yakirevitch, A.; Kronenberg, J., 2005: Mastoid subperiosteal abscess: a review of 51 cases. Objective: To present a Large study on subperiosteal abscess (SA) that represents the most frequent complication of acute mastoiditis.Method: A retrospective study was conducted on 49 patients who underwent mastoidectomy for SA.Results: The patien...

Anil, M.; Bal, A.; Anil, A.Berna.; Yavascan, O.; Kara, O.Deniz.; Aksu, N., 2010: Acute cyanosis in a child after percutaneous placement of a peritoneal dialysis catheter: question. Methemoglobinemia. Pediatric Nephrology 24(12): 2355, 2357-9