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Skin collagen conformation in canine spondylarthrosis


, : Skin collagen conformation in canine spondylarthrosis. Journal of Veterinary Medicine Series A 34(6): 439-444

Collagen type I conformation was studied in skin biopsy samples from 10 normal and 19 spondylarthrotic dogs. Collagen extractability and its content of aldehyde groups were increased in the patients. Both the shape and absorbance of ultraviolet absorption spectra, as well as the alterations of the optical rotatory dispersion in the extracts of the skin of the patients revealed that their collagen is either immature or degraded. The techniques may be useful in cases difficult to diagnoses and also in assessing the benefit of therapy.

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Accession: 001684895

PMID: 3113128

DOI: 10.1111/j.1439-0442.1987.tb00302.x

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