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The manufacture of medicinal alkaloids from the opium poppy - a review of a traditional biotechnology



The manufacture of medicinal alkaloids from the opium poppy - a review of a traditional biotechnology



Chemistry and Industry (5): 146-153



The prime purpose of this review is to trace the technical development of opiate manufacture and perhaps throw some light onto this relatively secretive sector of the pharmaceutical industry. That it is secretive is demonstrated by the paucicity of technical information in the public domain. In contrast, because of the United Nation's (UN) convention on drugs, some aspects are well collated and documented. This review falls into three parts: the opium poppy, and the two raw materials (crude 'drugs') derived from it, the conversion of the raw material to useful alkaloids, the semi-synthetic chemistry used to produce the finished pharmaceutical bulk actives. Illustrations of the commercial and therapeutic aspects of the business are provided throughout the review in order that the technical aspects are set in their proper context.

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Accession: 001711936

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