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Thin-layer chromatographic screening method for the tranquillizers azaperone, propiopromazine and carazolol in pig tissues



Thin-layer chromatographic screening method for the tranquillizers azaperone, propiopromazine and carazolol in pig tissues



Journal of Chromatography 436(1): 73-79



A procedure is described for the detection of azaperone, propiopromazine and carazolol in pig muscle, liver and kidney tissue. The method comprises extraction from an alkaline tissue homogenate with diethyl ether, followed by cleaning up and concentration of the extract on a silica gel solid-phase extraction column. Two-dimensional thin-layer chromatography on a silica plate was used for the detection of the tranquilizers. Detection levels were 25 .mu.g/kg-1 for propiopromazine, 50 .mu.g kg-1 for azaperone (or it metabolite azaperol) and 125 .mu.g kg-1 for carazolol. In pigs treated with the usual doses the presence of propiopromazine and azaperol could be established in kidney tissue 8 h after administration, while in injection sites all three tranquilizers could be detected.

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Accession: 001719019

Download citation: RISBibTeXText

PMID: 2897377

DOI: 10.1016/s0021-9673(00)94567-9


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