+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice



Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice



Nucleic Acids Research 15(4): 1459-1475



Normal and mutant alpha -1-antitrypsin genes from humans were microinjected into pronuclei of mice. Five transgenic mice were produced, 3 of which were mosaics. Progeny of the transgenic mice had high blood plasma concentrations of alpha -1-antitrypsin protein.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 001719864

Download citation: RISBibTeXText

PMID: 3029716

DOI: 10.1093/nar/15.4.1459


Related references

Tissue-specific regulation of human alpha 1-antitrypsin gene expression in transgenic mice. Dna 8(2): 101-108, 1989

Tissue specific expression of the human alpha 1 antitrypsin gene in hepatoma cells and transgenic mice. American Journal of Human Genetics 41(3 Suppl.): A211, 1987

Species specific and tissue specific expression of human alpha 1 antitrypsin in transgenic mice. Genes and Development 1(2): 161-171, 1987

Species- and tissue-specific expression of human alpha 1-antitrypsin in transgenic mice. Genes & Development 1(2): 161-171, 1987

The human alpha-1-antitrypsin gene is efficiently expressed from two tissue-specific promotors in transgenic mice. Nucleic Acids Research 15(18): 7519-7529, 1987

Development of a transgenic mouse system for the analysis of stages in liver carcinogenesis using tissue specific expression of sv 40 large t antigen controlled by regulatory elements of the human alpha 1 antitrypsin gene. Cancer Research 49(21): 6108-6117, 1989

Introduction and expression of the human gene for alpha 1 antitrypsin deficiency in transgenic mice. Gastroenterology 90(5 Part 2): 1366, 1986

Regulation of human alpha 1 antitrypsin gene expression in transfected cells and transgenic mice. Voellmy, R W , Et Al (Ed ) Icsu (International Council Of Scientific Union) Short Reports, Vol 7 Advances in Gene Technology: The Molecular Biology Of Development; 19th Miami Winter Symposium, Miami, Florida, Usa, February 9-13, Xvii+162p Cambridge University Press: Cambridge, England, Uk; New York, New York, Usa Illus 159, 1987

Tissue-specific expression of the human pyruvate dehydrogenase alpha (Pdha-1)/chloramphenicol acetyltransferase fusion gene in transgenic mice. Biochimica et Biophysica Acta 1305(3): 189-195, 1996

Tissue specific expression of the human alpha 1 antitrypsin gene. Journal of Cellular Biochemistry Suppl. (11 Part C): 129, 1987

An upstream regulatory region mediates high-level, tissue-specific expression of the human alpha 1(I) collagen gene in transgenic mice. Molecular and Cellular Biology 11(4): 2066-2074, 1991

Deletion of putative regulatory sequences in the first intron do not affect temporal and tissue-specific expression of a human pro-alpha-1 mini-gene in transgenic mice. Matrix 13(1): 75, 1993

Tissue-specific expression of the human alpha 1-antitrypsin gene is controlled by multiple cis-regulatory elements. Nucleic Acids Research 15(20): 8399-8415, 1987

Multiple tumors induced in transgenic mice by the expression of sv40 large t antigen controlled by the regulatory elements of the human alpha 1 antitrypsin gene. Laboratory Investigation 60(1): 86A, 1989

A 3,387 bp 5'-flanking sequence of the goat alpha-S1-casein gene provides correct tissue-specific expression of human granulocyte colony-stimulating factor (hG-CSF) in the mammary gland of transgenic mice. Transgenic Research 21(3): 485-498, 2012