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A nuclear magnetic resonance study of the interactions of the antimalarials chloroquine, quinacrine, quinine and mefloquine with dipalmitoylphosphatidylcholine bilayers



A nuclear magnetic resonance study of the interactions of the antimalarials chloroquine, quinacrine, quinine and mefloquine with dipalmitoylphosphatidylcholine bilayers



Molecular and Biochemical Parasitology 35(3): 199-207



The interaction of chloroquine, quinacrine, mefloquine and quinine with model dipalmitoylphosphatidylcholine (DPPC) bilayer membranes was studied using superscript 2H- and 31P-nuclear magnetic resonance (NMR). The results showed no significant perturbation of lipid bilayer structure by the presence of chloroquine up to a molar ratio of 1:2 of drug to lipid.

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Accession: 001740447

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PMID: 2787476

DOI: 10.1016/0166-6851(89)90206-5


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