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A nuclear magnetic resonance study of the interactions of the antimalarials chloroquine, quinacrine, quinine and mefloquine with lipids extracted from normal human erythrocytes



A nuclear magnetic resonance study of the interactions of the antimalarials chloroquine, quinacrine, quinine and mefloquine with lipids extracted from normal human erythrocytes



Molecular and Biochemical Parasitology 38(1): 33-39



The interaction of chloroquine, quinacrine, mefloquine, and quinine with lipid membranes re-formed from lipid extracts of normal human erythrocytes was studied using superscript 2H- and 31P-nuclear magnetic resonance (NMR). Inclusion of small amounts of chain-perdeuterated dipalmitoylphosphatidylcholine (DPPC) or dipalmitoylphosphatidylethanolamine (DPPE) as an superscript 2H-NMR probe allowed the effects of drugs on PC or PE components of the membranes to be studied separately.

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Accession: 001740448

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PMID: 2320052

DOI: 10.1016/0166-6851(90)90202-w


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