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Age influence on sucrose hydrolysis and on monosaccharide absorption along the small intestine of rat

, : Age influence on sucrose hydrolysis and on monosaccharide absorption along the small intestine of rat. Mechanisms of Ageing & Development 50(1): 49-56

The consequences of aging on the hydrolysis and absorption of hexoses was assessed in vitro using everted intestinal segments. Glucose and fructose were given either as a mixture of free monosaccharides or as a disaccharide solution (sucrose). The jejuno-ileum of 3- and 24-month-old rats was everted and divided into four equal segments. For each segment, the mucosal medium contained either sucrose (140 mM) or an equimolar mixture of glucose and fructose (70 mM). Monosaccharide concentrations in the mucosal and serosal media were measured after 1 h of incubation at In the young adult, glucose absorption was enhanced when given as sucrose. In contrast, in the aged rat, free glucose or glucose released from sucrose hydrolysis were similarly absorbed. Independently of age, fructose was better absorbed when provided in a mixture of free monosaccharides. The intestinal segments (and especially the ileum), of the aged animals exhibited higher abilities to hydrolyse sucrose and to absorb monosaccharides indicating a normal or increased intestinal hydrolytic activity and absorptive capacity for dietary sugars.

Accession: 001748229

PMID: 2630829

DOI: 10.1016/0047-6374(89)90058-4

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Related references

Gray, G.M.; Ingelfinger, F.J., 1966: Intestinal absorption of sucrose in man: interrelation of hydrolysis and monosaccharide product absorption. A double tube lumen was placed at different parts of the intestine in 32 young normal adults and sucrose solution or a mixture of glucose and fructose was infused at 15 ml per min. Intestinal samples were collected and after the first 30 min of an...

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