+ Translate

Age-related changes in lipid metabolism in rats: the consequence of moderate food restriction

, : Age-related changes in lipid metabolism in rats: the consequence of moderate food restriction. Biochimica et Biophysica Acta 963(2): 237-242

Male Sprague-Dawley rats, 3 weeks of age, received one of the four following dietary manipulations until 9 months of age: group AD, fed ad libitum; group R, restricted to 75% of food intake of group AD; group RAD, restricted until 5 months of age and then fed ad libitum; group ADR, fed ad libitum until 5 months of age and the restricted. The concentration of serum total and HDL cholesterol tended to be higher in group AD and than in all groups that had experienced food restriction. Liver cholesterol was higher in groups AD and RAD than in groups R and ADR. Activity of hepatic microsomal hydroxymethylglutaryl-CoA reductase was comparable, whereas sterol synthesis from mevalonate was significantly higher in groups R and ADR than in groups AD and RAD. Cholesterol 7 alpha-hydroxylase activity also tended to be higher in groups R and ADR. It seems likely that hepatic cholesterol homeostasis functions effectively even when moderate food restriction was started after the growing period. In addition, food restriction reduced the ratio of arachidonate to linoleate, suggesting inhibition of the desaturation system.

Accession: 001748293

PMID: 3196729

DOI: 10.1016/0005-2760(88)90286-x

Download PDF Full Text: Age-related changes in lipid metabolism in rats: the consequence of moderate food restriction

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Vaquero, M.P.; Navarro, M.P., 1993: Influence of moderate food restriction on calcium metabolism in pregnant rats. Two groups of female rats, non-pregnant (NP) and pregnant (P1), were fed ad libitum. A second group of pregnant rats (restricted diet, P2) were restricted for 14 d to the same intake as NP, and their ration was then increased by 5% from d 14 to d...

Harada K.; Yonemoto K., 1989: Effects of food restriction and long term moderate exercise on basal metabolism of rats. Japanese Journal of Physiology 39(SUPPL): S288

Couto, G.E.C.; Couto, R.C.; D.S.lva, M.H.G.G.mes; Oyama, L.M.; Fisberg, M.; Ribeiro, E.B.; Nascimento, C.M.O., 1999: Food restriction and exercise in monosodium glutamate obese rats Effect on lipid metabolism. Medicine & Science in Sports & Exercise 31(5 SUPPL ): S371, May

Cleary, M.P.; Muller, S.; Lanza-Jacoby, S., 1987: Effects of long-term moderate food restriction on growth, serum factors, lipogenic enzymes and adipocyte glucose metabolism in lean and obese Zucker rats. The effects of long-term moderate food restriction were assessed in lean and obese male Zucker rats. A 30% reduction in food intake from 5 to 68 wk of age resulted in parallel lowering of body weight in both lean and obese rats compared to their r...

Li-Juan; Wu-Zhi-Yong; Wei-Mei-Juan, 2005: Effect of food restriction and kidney tonifying herbs on energy status, serum lipid metabolism, ovulation in androgen-sterilized rats. Purpose To explore the effect of food restriction and kiney tonifying herbs on energy status, serum lipid metabolism, ovulation in androgen-sterilized rat(ASR). Methods ASR model was established by subcutaneous injection of testosterone propionate...

Okey, R.; Lyman, M.M.; Einset, B.M., 1959: Effect of food restriction on cholesterol metabolism. 1. Moderate limitation during late adolescence. Two reducing experiments with adolescent rats fed adequate diets with 15% protein from weaning till the weights of 200 g (female) and 250 g (male) were attained. Half received cholesterol supplementation[long dash]half did not. Certain pre-diet ra...

Moriyama, T.; Miyazawa, H.; Tomohiro, M.; Fujikake, N.; Samura, K.; Nishikibe, M., 2006: Beneficial effect of moderate food restriction in toxicity studies in rats. Moderate food restriction (FR) has been established as a nutritionally appropriate and well-controlled method with long-term beneficial effects in conducting toxicity and carcinogenicity studies in rodents. This study describes the early effects o...

Shibata, K.; Nakata, C.; Fukuwatari, T., 2015: Moderate food restriction suppresses the conversion of L-tryptophan to nicotinamide in weaning rats. Calorie restriction leads to a change in the metabolism of nutrients. Nicotinamide is biosynthesized from L-tryptophan. We attempted to determine the effects of food restriction on the biosynthesis of nicotinamide from L-tryptophan. Weaning male r...

Kaunitz, H.; Mckay, D.G., 1964: Food Restriction And Lipid Metabolism In Pregnancy. In order to study the effects of reduced food intake during pregnancy on tissue and serum lipids, a paired feeding experiment was carried out on pregnant rats in which deprived rats were given 30% of the daily intake of their freely eating control...

Escrivá, F.; Gavete, M.Lucía.; Fermín, Yín.; Pérez, C.; Gallardo, N.; Alvarez, C.; Andrés, A.; Ros, M.; Carrascosa, Jé.M., 2007: Effect of age and moderate food restriction on insulin sensitivity in Wistar rats: role of adiposity. Insulin resistance develops with ageing in humans and rodents. Here, we have studied the evolution of insulin sensitivity with ageing trying to discriminate the role of adiposity front that of ageing in this process. We performed oral glucose tol...