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Biological disposition and percutaneous absorption of bifonazole in animals and man



Biological disposition and percutaneous absorption of bifonazole in animals and man



Recent trends in the discovery, development and evaluation of antifungal agents: 383-405



Biological disposition and percutaneous absorption of bifonazole were investigated in 7 animal spp. and in man using a specific chromatographic assay and radiometric methods. In humans (10 volunteers), a single topical application of bifonazole as a 1% cream or a 1% solution yielded bifonazole plasma levels <1 ng/ml. After repeated applications (14 d), the bifonazole concn in plasma generally amounted to <5 ng/ml even after treatment of large skin areas.

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Accession: 001764994

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