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cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases



cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases



Dna and Cell Biology 9(6): 415-424



Based on the concept of sequence conservation around the active sites of serine proteinases, the polymerase chain reaction was used to amplify mRNA and enabled a 260-bp probe to be generated which was used to screen a mouse pituitary cDNA library. The primers used were derived from the cDNA sequence of active sites Ser and Asn of human furin. Two cDNA sequences were obtained from a number of positive clones.

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Accession: 001768816

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PMID: 2169760

DOI: 10.1089/dna.1990.9.415


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