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Changes in copper and iron utilization in copper-deficient rats fed fructose, sucrose or cornstarch



Changes in copper and iron utilization in copper-deficient rats fed fructose, sucrose or cornstarch



Nutrition reports international 40(1): 207-217



A 31-day study was conducted to compare the effects of carbohydrate (CHO) type on copper (Cu) and iron (Fe) status during Cu deficiency. Male rats (n=36) were fed Cu-deficient (-Cu) or Cu-adequate (+Cu) diets that contained cornstarch (CS), sucrose (SUC), or fructose (FR). Both SUC and FR enhanced the severity of Cu deficiency. However, the relative effects of SUC and FR depended on the indices of Cu or Fe metabolism that was examined. Rats fed -CuFR and CuSUC diets had equally lower liver Cu levels and equally higher liver weights when compared to rats fed -CuCS. In contrast, hemoglobin, hematocrit, and Fe in tibia and intestine were lower in rats fed -CuFR compared to -CuCS while the levels in rats fed -CuSUC were either intermediate between -CuFR and -CuCS or were similar to those fed -CuCS.

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Accession: 001772356

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