EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Comparative efficacies of aztreonam and chloramphenicol in children with typhoid fever


Pediatric Infectious Disease Journal 9(1): 44-48
Comparative efficacies of aztreonam and chloramphenicol in children with typhoid fever
We compared aztreonam with chloramphenicol in a randomized trial involving the treatment of 36 children with typhoid fever. Eighteen children were randomized to receive aztreonam, 150 mg/kg/day intravenously, and 18 to receive chloramphenicol, 100 mg/kg/day orally. On entry in the study the clinical characteristics of the two treatment groups were comparable. The duration of therapy was 14.9 +/- 3.6 days for the aztreonam group and 12.8 +/- 2.6 days for the chloramphenicol group. The mean duration of fever was 5.9 +/- 3.1 days and 4.05 +/- 2.1 days for aztreonam and chloramphenicol groups respectively (P greater than 0.05). Clinical cure was observed in all patients treated with aztreonam and in 17 of 18 children given chloramphenicol; one patient died in the latter group. There were no relapses in either group. We observed clinical adverse reactions during the treatment with aztreonam in 2 patients. All strains of Salmonella typhi were susceptible to aztreonam, 1 strain was resistant to chloramphenicol and 3 strains were resistant to ampicillin. Aztreonam appears to be a satisfactory alternative to chloramphenicol in cases of typhoid fever caused by resistant strains or when chloramphenicol is contraindicated.


Accession: 001780851

PMID: 2405349

DOI: 10.1097/00006454-199001000-00010



Related references

Randomized comparison of aztreonam and chloramphenicol in treatment of typhoid fever. Antimicrobial Agents and ChemoTherapy 38(3): 558-562, 1994

Successful aztreonam treatment of acute typhoid fever after chloramphenicol failure. Scandinavian Journal of Infectious Diseases 22(4): 505-506, 1990

A comparative study of cefixime and chloramphenicol in children with typhoid fever. Jpma. Journal of the Pakistan Medical Association 48(4): 106-107, 1998

A comparative study of chloramphenicol and furazolidone in the treatment of typhoid fever in children. Indian Pediatrics 15(9): 769-776, 1978

Treatment of 100 cases of typhoid fever in children with chloramphenicol; comparative study with 159 patients who did not receive the drug. Revista Medica de Chile 79(5): 307-313, 1951

Comparative study of the treatment of severe typhoid fever with chloramphenicol & cortisone & chloramphenicol alone. Revista Medica de Chile 85(12): 695-707, 1957

Comparative studies on the treatment of typhoid fever with chloramphenicol alone and with synergic association of chloramphenicol with paraaminobenzoic and ascorbic acids. Omnia Medica. Supplemento 3(4): 401-420, 1952

Comparative trial of Co-trimoxazole and Chloramphenicol in Typhoid Fever. British Medical Journal 1(5845): 82-83, 1973

A comparative trial of furazolidone and chloramphenicol in typhoid fever. Journal of the Indian Medical Association 55(4): 131-133, 1970

A comparative trial of hetacillin and chloramphenicol in typhoid fever. Journal of Pediatrics 77(3): 471-473, 1970