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Dietary cholesterol and/or n-3 fatty acid modulate delta 9-desaturase activity in rat liver microsomes


Dietary cholesterol and/or n-3 fatty acid modulate delta 9-desaturase activity in rat liver microsomes



Biochimica et Biophysica Acta 962(3): 330-336



ISSN/ISBN: 0006-3002

PMID: 2901857

.DELTA.9-Desaturase activity and fatty acid composition of liver microsomal phospholipids in rats fed diets enriched with either saturated (hydrogenated beef tallow) or .alpha.-linolenic (linseed oil) or eicosapentaenoic and docosahexaenoic (fish oil) acids with or without 2% cholesterol supplementation were investigated. Both the linseed oil and the fish oil diets inhibited .DELTA.9-desaturase activity in the rat liver microsomes. The inhibition was greater when feeding fish oil (90%) compared with the linseed oil (60%) diet. Dietary cholesterol feeding accelerated conversion of palmitic (16:0) to palmitoleic (16:1) acid, irrespective of the fatty acid supplement. Feeding the linseed oil diet decreased, while feeding the fish oil diet increased synthesis of the monounsaturated fatty acids of n - 7 series (palmitoleic and vaccenic acid) and decreased 18:1(n - 9) in microsomal membranes lipids when compared with animals fed beef tallow. Addition of 2% cholesterol to the otherwise low cholesterol diets led to accumulation of 16:1(n - 7), 18:1(n - 7) and 18:1(n - 9) in microsomal membranes. These results suggest that .DELTA.9-desaturase activity is dependent on the cholesterol content as well as the n - 3 fatty acid content of microsomal membranes on which is localized.

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Accession: 001798820

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