+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Efficacy of addition of exogenous lactase to milk in adult lactase deficiency

Efficacy of addition of exogenous lactase to milk in adult lactase deficiency

American Journal of Gastroenterology 83(10): 1145-1149

The efficacy of lactose by Kluyveromyces lactis in hydrolyzing milk lactase and reducing milk intolerance symptoms was tested in 52 proved lactose malabsorbers. The enzyme was added to milk administered to the patients, and H2 breath excretion (as an index of carbohydrate malabsorption), was determined by gas chromatograph technique, and milk intolerance symptoms were recorded. H2 mean excretion was 78.3 .+-. 5.49 ppm after administration of intact whole milk 500 ml (test A), 43.5 .+-. 4.99 ppm when lactase 2000 U was added to milk 500 ml immediately before administration (test B); 36.7 .+-. 5.01 ppm when milk 500 ml was incubated for 12 h with lactase 1000 U (test C), and 29.7 .+-. 4.35 ppm when the incubation was prolonged for 24 h (test D). Symptoms score was: test A = 5.85 .+-. 0.56, test B = 3.71 .+-. 0.45, test C = 2.77 .+-. 0.63, test D = 1.7 .+-. 0.68. A correlation index of r = 0.44 (p < 0.01) was obtained between reduction in H2 mean excretion and reduction in symptoms score of a single individual. The addition of this lactase to milk seems to be effective in correcting lactose malabsorption, thus representing a convenient approach in milk intolerance.

(PDF emailed within 1 workday: $29.90)

Accession: 001821160

Download citation: RISBibTeXText

PMID: 3138908

Related references

A racial difference in incidence of lactase deficiency A survey of milk intolerance and lactase deficiency in healthy and adult males. J Amer Med Ass2: 968-972, 1966

A racial difference in incidence of lactase deficiency. A survey of milk intolerance and lactase deficiency in healthy adult males. JAMA 197(12): 968-972, 1966

Lactase deficiency Biologic and medical aspects of the adult human lactase polymorphism. King, Richard A , Rotter, Jerome I , Motulsky, Arno G Oxford Monographs on Medical Genetics; The genetic basis of common diseases : 305-325, 1992

Immunocytochemical heterogeneity of lactase-phlorizin hydrolase in adult lactase deficiency. Gastroenterology 105(1): 51-59, 1993

Enzyme replacement therapy for primary adult lactase deficiency. Effective reduction of lactose malabsorption and milk intolerance by direct addition of beta-galactosidase to milk at mealtime. Gastroenterology 87(5): 1072-1082, 1984

Immunocytochemical heterogeneity of lactase phlorizin hydrolase in proximal intestine in adult lactase deficiency. Journal of Cell Biology 115(3 PART 2): 58A, 1991

Separation of primary lactase deficiency, secondary lactase deficiency and lactase persistence without small bowel biopsy Serum lactose and galactose after lactose challenge. Gut 42(SUPPL 1): A22, March, 1998

Intestinal lactase deficiency and milk drinking capacity in the adult. American Journal of Clinical Nutrition 31(9): 1499-1503, 1978

Breath hydrogen for detecting lactase deficiency. II. Relation between intestinal lactase activity, breath hydrogen and blood glucose during lactose tolerance test in 73 adult patients. Gastroenterologie Clinique et Biologique 5(1): 29-36, 1981

Adult human milk intolerance and intestinal lactase deficiency. A review. Journal of Dairy Science 52(5): 585-587, 1969

Impaired trafficking and subcellular localization of a mutant lactase associated with congenital lactase deficiency. Gastroenterology 136(7): 2295-2303, 2009

Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency. American Journal of Human Genetics 78(2): 339-344, 2006

Two novel mutations in the lactase gene in a Japanese infant with congenital lactase deficiency. Tohoku Journal of Experimental Medicine 227(1): 69-72, 2012

Evaluation of oral lactase tablets in children with lactose intolerance intestinal lactase deficiency. Pediatric Research 25(4 PART 2): 125A, 1989