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Efficacy of ronidazole (Ridzol-S MSD) in the prevention and treatment of Trypanosoma (Trypanozoon) brucei evansi infection in rats



Efficacy of ronidazole (Ridzol-S MSD) in the prevention and treatment of Trypanosoma (Trypanozoon) brucei evansi infection in rats



Revue de Medecine Veterinaire 145(4): 291-296



Twenty eight Wistar rats in groups of 4 were given Ridzol-S MSD (10% ronidazole, 733 ppm active ingredient) with food, ad libitum for 3, 6 or 9 days. The treatment was given prophylactically, starting on the day of infection with T. brucei evansi, or curatively, starting 3 days pi. Parasitaemia levels were evaluated by the "matching method" of Herbert and Lumsden from day 3 to 55 pi. Survival, percentage of positive rats and mortality rate were also calculated.

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