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Epizootiological studies on porcine atrophic rhinitis. XV. Results of local immunization with a live Bordetella bronchiseptica strain in a large-scale pig herd affected by atrophic rhinitis



Epizootiological studies on porcine atrophic rhinitis. XV. Results of local immunization with a live Bordetella bronchiseptica strain in a large-scale pig herd affected by atrophic rhinitis



Acta Veterinaria Hungarica 36(3-4): 195-204



A natural avirulent Bordetella bronchiseptica mutant was isolated from a swine herd free from the clinical signs and gross pathological lesions of atrophic rhinitis (AR). In experiments with mice, the mutant proved to be atoxic. The strain could be reisolated from the nasal mucosa of SPF piglets for 21 days and was apathogenic for swine. The live strain, was used in four schemes of immunization experiments in four large-scale swine herds severely affected by AR. The inoculum was 5 .times. 108 CFU per nostril, applied on the nasal mucosa. The pig herds were infected by both exotoxin-producing B. bronchiseptica and exotoxin-producing Pasteurella multocida strains. In scheme I, the piglets were vaccinated at birth, in scheme II at birth and at 15 days old, in scheme III at birth and at 30 days old, and in scheme IV at birth and at 60 days old. The vaccinated groups contained 120-1800 piglets in the various herds. The bacteriological, immunological and gross pathological examinations performed in the four herds have led us to the following main conclusions: Immunization induced, within three weeks, protective mucosal immunity which prevented virulent B. bronchiseptica strains from colonizng the nasal mucosa, and reduced the severity of infection by virulent P. multocida. In piglets immunized once the protection against B. bronchiseptica lasted at least 4-6 weeks, while in those vaccinatd twice as long a 2 to 3 months. In the nasal secretion of the immunized piglets higher titres of antibodies were found than in the controls. These antibodies reacted with both the B. bronchiseptica and the P. multocida antigens. In agreement with results of the bacteriological and immunological studies, the gross pathological findings indicate that two immunizations with the B. bronchiseptica strain may reduce the severity of AR by 65-80% in pig herds affected by AR, particularly if the second vaccination takes place at 30 dyas old.

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Accession: 001825682

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PMID: 2978213


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