EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Excess dietary methionine decreases indices of copper status in the rat



Excess dietary methionine decreases indices of copper status in the rat



Annals of Nutrition & Metabolism 34(2): 93-97



Two groups (n = 5) of male weanling Wistar rats were housed individually and fed copper (Cu)-deficient (0.5 mg Cu/kg) diets either with or without methionine supplementation (18 g/kg) for 49 days. Plasma caeruloplasmin (EC 1.16.3.1) and erythrocyte superoxide dismutase (EC 1.15.1.1, CuSOD) activities were measured in blood. Tissue Cu levels and the activities of cytochrome c oxidase (EC 1.9.3.1, CCO) and CuSOD were measured in the heart and liver. Hepatic activities of the sulfhydryl-sensitive enzymes, creatine kinase (EC 2.7.3.2), fumarase (EC 4.2.1.2) glutathione S-transferase (EC 2.5.1.18) and lipoamide dehydrogenase (EC 1.6.4.3) were also measured. Apart from cardiac CCO activity all of the measured indices of Cu status were found to be significantly (p less than 0.05) decreased in the methionine supplemented rats. Although fumarase activity was significantly (p less than 0.05) decreased in the methionine-supplemented animals compared with controls, the activities of the other sulfhydryl-sensitive enzymes were not significantly decreased. These results suggest that some of the toxic effects of excess dietary methionine may be mediated through interference with copper metabolism rather than through the previously postulated inhibition of sulfhydryl-sensitive enzymes by metabolites of methionine.

(PDF emailed within 1 workday: $29.90)

Accession: 001831054

Download citation: RISBibTeXText

PMID: 2164346



Related references

Influence of dietary excess methionine on the relationship between dietary copper and the concentration of copper and iron in organs of broiler chicks. Journal of Nutrition 111(9): 1630-1640, 1981

Eimeria acervulina infection in chicks fed excess copper in the presence or absence of excess dietary methionine. Journal of Animal Science 54(5): 989-997, 1982

Effect of dietary copper and cystine on copper balance surface losses and selected indices of copper status of young men. FASEB Journal 4(3): A394, 1990

Effect of dietary copper and carbohydrate on copper homeostasis and indices of copper status in men. Journal of Trace Elements in Experimental Medicine 5(2): 125, 1992

Effects of supplemental copper and excess dietary methionine on the growing performance of broiler chicks. Korean Journal of Animal Science 26(7): 621-630, 1984

Metabolic implications of methionine excess. Effects of methionine excess, dietary protein, fasting, cortisol and insulin on certain hepatic enzyme activities involved in transsulfuration, glycolysis, gluconeogenesis and lipogenesis in adapted adult rats. Annales de Biologie Animale, Biochimie, Biophysique 19(2A): 343-353, 1979

Effect of excess dietary methionine and dietary protein level on methionine phenylpyruvate transaminase activity in the kitten. Federation Proceedings 44(5): 1522, 1985

Effect of dietary copper and carbohydrate on copper absorption retention and status indices. FASEB Journal 6(4): A1210, 1992

Relationship between dietary copper intake and indices of copper status in men premenopausal and postmenopausal women. FASEB Journal 3(3): A361, 1989

Indices of copper status at three levels of dietary copper. American Journal of Clinical Nutrition 45(4): 854, 1987

Excess dietary histidine decreases the liver copper level and serum alanine aminotransferase activity in Long-Evans Cinnamon rats. British Journal of Nutrition 90(3): 573-579, 2003

Effect of excess dietary iron as ferrous sulfate and excess dietary ascorbic acid on liver zinc copper and sulfhydryl groups and the ovary. Federation Proceedings 45(4): 977, 1986

Effect of excess dietary copper, iron or zinc on the tocopherol and selenium status of growing pigs. Journal of Animal Science 68(8): 2407-2413, 1990

The effect of excess dietary l methionine on the ability of the chick intestine to absorb methionine. Japanese Journal of Zootechnical Science 52(1): 53-57, 1981

Influence of excess dietary methionine on L-(35S) methionine incorporation into different brain areas in rats. Acta Nutrimenta Sinica 17(1): 12-16, 1995