+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Excitatory and inhibitory effects of gastrin peptides on gastric motility in sheep

Excitatory and inhibitory effects of gastrin peptides on gastric motility in sheep

American Journal of Physiology 257(2 Pt 2): R388-R395

In conscious sheep, tetragastrin, pentagastrin, and synthetic human gastrin I, injected either subcutaneously or intravenously in doses of 156-5,200 pmol/kg body wt, inhibited the vagally dependent cyclical motility of the reticulum and rumen, whereas in vitro pentagastrin (10(-12) to 10(-6) M) had no demonstrable inhibitory or excitatory effects on intrinsically active or quiescent muscle of the reticulum, rumen, and omasal leaves. In vitro pentagastrin (10(-18) to 10(-4) M) stimulated quiescent and intrinsically active longitudinal and circular muscles of the body of the omasum and the body and antrum of the abomasum and potentiated contractile responses of antral muscle to electrical stimulation of intramural cholinergic nerves. Responses in the presence of hexamethonium, atropine, and tetrodotoxin indicated that the excitatory effects on mixed nerve-muscle preparations of omasal and abomasal tissue were mediated both through stimulation of cholinergic neurones and by direct actions on the muscle. In vitro the ovine stomach shows marked regional differences in both its response and sensitivity to gastrin peptides, and their inhibitory effects on reticuloruminal motility in vivo appear to be other than direct.

(PDF emailed within 1 workday: $29.90)

Accession: 001831109

Download citation: RISBibTeXText

PMID: 2569839

Related references

Inhibitory effects of gastric electrical stimulation on ghrelin-induced excitatory effects on gastric motility and food intake in dogs. Scandinavian Journal of Gastroenterology 41(8): 903-909, 2006

Excitatory and inhibitory effects of vagus stimulation on gastric motility in the cat. Acta Physiol Scand 57(4): 309-316, 1963

Excitatory and inhibitory effects of intracisternally administered clonidine on rat gastric motility. Japanese Journal of Pharmacology 64(SUPPL 1): 323P, 1994

Gastrin group peptides and cholecystokinin 8 sites of action to control the motility of the reticulum forestomach in sheep. Gut 25(11): A1308-A1309, 1984

The central neural mechanism of the gastric motility in the dog's medulla oblongata on the vagal inhibitory and excitatory reflexes. Nihon Heikatsukin Gakkai Zasshi 12(2): 77-85, 1976

Effect of porcine gastrin releasing peptide on gastric secretion and motility and the release of hormonal peptides in conscious cats. Peptides (New York) 8(3): 423-430, 1987

Mechanisms of the excitatory and inhibitory effects of vasopressin on colonic motility. Gastroenterology 106(4 SUPPL ): A587, 1994

Gastrin cholecystokinin like peptides and their effects on gut motility in the atlantic cod gadus morhua. Regulatory Peptides 13(1): 77, 1985

Effects of antibodies to gastric inhibitory peptide on gastric acid secretion and gastrin release in the dog. Gastroenterology 84(5 Pt 1): 941-948, 1983

Excitatory and inhibitory vagal effects on motility of the intact rabbit stomach. Bollettino della Societa Italiana di Biologia Sperimentale 58(6): 300-305, 1982

Putative mechanisms involved in excitatory and inhibitory effects of somatostatin on intestinal motility. American Journal of Physiology 257(4 Pt 1): G532-G538, 1989

Studies on gastrointestinal motility of ruminants. I. Effects of bethanechol and neo-stigmine on gastric motility of sheep.. J. Jap. vet. med. Ass, 16: 286-292, 1963

Evidence of the inhibitory effect of vagal input on gastric motility in conscious sheep. Bulletin de l' Academie Veterinaire de France 61(3): 297-302, 1988

Effects of antral gastrin II on the gastric secretion and motility in rats. Sbornik Vedeckych Praci Lekarske Fakulty Karlovy Univerzity V Hradci Kralove. Supplementum 19(1): 89-96, 1975

Excitatory effects of motilin in the hippocampus on gastric motility in rats. Brain Research 984(1-2): 33-41, 12 September, 2003