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Exocrine pancreatic degeneration during vitamin E and selenium deficiency in rats



Exocrine pancreatic degeneration during vitamin E and selenium deficiency in rats



Nutrition reports international 40(1): 151-159



This study added pancreatic degeneration to the histopathology of vitamin E and selenium deficiency in rats and corroborated changes in coagulation factors. Weanling rats consumed semipurified diets for 1, 1.5, or 2 months in a factorial experiment including 0 or 100 mg a-tocopherol per Kg diet and 0 or .1 mg added Se per Kg diet. Vitamin E deficiency caused a milk increase in plasma fibrinogen. In addition to skeletal myopathy and hepatic necrosis, there was (especially as a result of combined deficiency) multifocal vacuolar degeneration of exocrine pancreatic cells previously unreported in rats.

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Accession: 001831226

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