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Expansion of a T lymphocyte subpopulation (CD3+,4-,8-) after immunodepression associated with disseminated histoplasmosis

Expansion of a T lymphocyte subpopulation (CD3+,4-,8-) after immunodepression associated with disseminated histoplasmosis

International Archives of Allergy and Applied Immunology 84(3): 311-315

A major subpopulation of T lymphocytes bearing a high density of CD3 (T3/Leu 4) with no detectable CD4 (T4/Leu 3a) or CD8 (T8/Leu 2a) was found in a 26-yr-old man with cardiomyopathy. Previously the patient had developed disseminated Histoplasma capsulatum infection which had been associated with a profound anergic state. The proportion of CD3+ lymphocytes that bore the phenotype CD3+,4-,8- was increasing in the absence of reactivation of the histoplasmosis.

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Accession: 001831302

Download citation: RISBibTeXText

PMID: 3498697

DOI: 10.1159/000234440

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