+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Experimental cryptosporidiosis in a primate model

Experimental cryptosporidiosis in a primate model

Journal of Infectious Diseases 161(2): 312-315

Cryptosporidium causes a disease in infant macaques that is clinically, histologically, and microbiologically indistinguishable from that seen in young children. A reproducible experimental model of cryptosporidiosis has been developed in pigtailed macaques (Macaca nemestrina) and used to study the infectious dose of oocysts and the effect of inoculum size on severity of disease. Inoculation with either 2 .times. 105 or 10 oocysts via nasogastric tube resulted in clinical enteritis and the fecal passage of large numbers of cryptosporidial oocysts in all four primates studied. The size of the inoculum had no apparent effect on the severity or duration of disease. Rechallenge 2 weeks after resolution of the primary infection demonstrated partial acquired immunity. The small inoculum size coupled with the passage of large numbers of oocysts contributes to the highly contagious nature of cryptosporidiosis among captive primates and may be relevant to the epidemiology and control of cryptosporidiosis in humans.

(PDF emailed within 0-6 h: $19.90)

Accession: 001831696

Download citation: RISBibTeXText

PMID: 2299211

DOI: 10.2307/30126093

Related references

Use of a primate as an experimental model on board SPACELAB: definition of a two-primate biological facility. Life Sciences and Space Research 16: 127-130, 1978

Reactive nitrogen and oxygen species ameliorate experimental cryptosporidiosis in the neonatal BALB/c mouse model. Infection and Immunity 67(11): 5885-5891, 1999

Fulminant cryptosporidiosis after near-drowning: a human Cryptosporidium parvum strain implicated in invasive gastrointestinal adenocarcinoma and cholangiocarcinoma in an experimental model. Applied and Environmental Microbiology 78(6): 1746-1751, 2012

Mri of experimental parkinsonism a primate model. Investigative Radiology 24(12): S127, 1989

Experimental primate stroke model. Neurosurgery 18(3): 388-389, 1986

A new experimental model of choreoathetosis in the primate. Journal of Physiology (Cambridge) 350: 36P, 1984

Cidofovir treatment of variola in the hemorrhagic smallpox primate model and the IV monkeypox primate model. Antiviral Research 57(3): A78, February, 2003

Experimental alcoholic hepatitis: a new primate model. Science 182(4113): 712-713, 1973

Experimental model in a primate predisposed to epilepsy. Schmidt, D And P L Morselli (Ed ) L E R S (Laboratoires D'etudes Et De Recherches Synthelabo) Monograph Series, Vol 5 Intractable Epilepsy: Experimental And Clinical Aspects; Workshop, Saint Germain-En-Laye, France, April 22-23, 1985 Xv+269p Raven Press: New York, New York, Usa Illus 39-60, 1986

The non-human primate experimental glaucoma model. Experimental Eye Research 141: 57-73, 2016

A model of selective experimental ischemia in the primate thalamus. Stroke 16(3): 493-501, 1985

Toxemia of pregnancy the development of an experimental model in the primate. Obstetrics & Gynecology 29(4): 637-638, 1972

A primate model for the experimental production of Cushing's disease. Surgical Forum 21(4): 87-88, 1970

Experimental transvitreal cyanoacrylate retinopexy in a primate model. American Journal of Ophthalmology 103(6): 782-789, 1987