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Experimental intravitreal ketoconazole in DMSO

Experimental intravitreal ketoconazole in DMSO

Retina 8(3): 210-215

To determine the ocular toxicity of intravitreal ketoconazole, doses of 15-2240 micro g dissolved in 0.1 ml of 100% dimethyl sulphoxide (DMSO) were injected into the vitreous bodies of 24 rabbits. Doses of ketoconazole <less or =>540 micro g resulted in no toxicity to the eyes, whereas doses of 720 micro g showed toxic effects in the retina measured by fusion of the flicker response at 60 hz in electroretinographical testing at 1 wk and 2 months after a single injection of ketoconazole.

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Accession: 001831844

Download citation: RISBibTeXText

PMID: 3266021

DOI: 10.1097/00006982-198808030-00012

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