EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Experimental sodium depletion and salt taste in normal human volunteers



Experimental sodium depletion and salt taste in normal human volunteers



American Journal of Clinical Nutrition 51(5): 881-889



To examine the sensory effects of extreme sodium depletion in humans, 10 normal volunteers were fed a very-low-sodium diet and were treated with diuretics for 10 d. Urine samples were collected and blood was drawn for hormone analyses. Taste tests included threshold and intensity judgments of salt (NaCl) and sucrose and preferences for salt and sucrose in foods. Subjects also rated the pleasantness of 29 foods listed on a questionnaire. Substantial sodium depletion was induced in all subjects. Salt thresholds decreased in a majority of the subjects whereas preference judgments for salt in foods tended to be greater during the depletion period. The changes in pleasantness of the 29 foods revealed that saltier foods were substantially more attractive during the depletion period than during the pre- and postdepletion periods. These data indicate that experimental sodium depletion in humans is followed by moderate sensory changes and an increased preference for salty foods.

(PDF emailed within 0-6 h: $19.90)

Accession: 001831961

Download citation: RISBibTeXText

PMID: 2185626

DOI: 10.1093/ajcn/51.5.881



Related references

Haemodynamic and renal responses to oral losartan potassium during salt depletion or salt repletion in normal human volunteers. Journal of Cardiovascular Pharmacology 25(4): 511-517, 1995

Effect Of Experimental Salt Depletion And Aldosterone Load On Sodium And Chloride Concentration In The Sweat Of Patients With Cystic Fibrosis Of The Pancreas And Of Normal Children. Archives of Disease in Childhood 39: 61-65, 1964

The effect of different salt intakes on exchangeable body sodium and on sodium chloride depletion during long term bendroflumethiazide administration to the normal rat. Acta Pharmacologica et Toxicologica 27(5): 349-362, 1969

Experimental zinc depletion and altered taste perception for sodium chloride in young adult males. American Journal of Clinical Nutrition 34(5): 848-852, 1981

Effects of saline infusion and salt depletion on sodium transport by leukocytes in normal man. Clinical Science & Molecular Medicine 49(3): 16P, 1975

Effect of Maillard reacted peptides on human salt taste and the amiloride-insensitive salt taste receptor (TRPV1t). Chemical Senses 33(7): 665-680, 2008

Experimental potassium depletion in normal human subjects. II. Renal and hormonal factors in the development of extracellular alkalosis during depletion. Journal of Clinical Investigation 38(7): 1149-1165, 1959

Effects of experimental salt depletion on urinary prostanoid excretions in normal women. Prostaglandins Leukotrienes & Essential Fatty Acids. 58(3): 237-242, Ch, 1998

Effect of salt depletion on sodium ion transport from human erythrocytes. Klinische Wochenschrift 63 Suppl 3: 45-48, 1985

Taste preference for sodium chloride in dahl salt sensitive and salt resistant rats fed high or low levels of sodium chloride in weaning diets. Society for Neuroscience Abstracts 10(1): 250, 1984

Salt taste adaptation: the psychophysical effects of adapting solutions and residual stimuli from prior tastings on the taste of sodium chloride. Perception 8(4): 441-476, 1979

Effect of sodium/potassium salt (potash) on the bioavailability of ibuprofen in healthy human volunteers. European Journal of Drug Metabolism and Pharmacokinetics 28(2): 93-99, 2003

Comparative bioavailability study on naproxen betainate sodium salt monohydrate and naproxen sodium salt in healthy volunteers. Arzneimittel-Forschung 47(4): 385-389, 1997

Blood pressure, salt taste and sodium excretion in rats exposed prenatally to high salt diet. Clinical and Experimental Pharmacology & Physiology 12(3): 217-220, 1985

Different responses to sodium bicarbonate and carbicarb in normal human volunteers. Clinical Research 37(2): 346A, 1989