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Heat shock proteins and immunity



Heat shock proteins and immunity



Research in Immunology 140(7): 653-659



Antibodies to a 56 kDa nuclear protein have been found in the sera of 85% of patients with myositis using an immunoblotting technique. This auto-antibody appears to be relatively disease-specific though more frequently detectable in both adult and childhood onset dermatomyositis. In adult patients with myositis the anti-56 kDa antibody level reflects disease activity. This antibody is thus much more frequently found than previously described disease-specific autoantibodies in patients with myositis such as the Jo-1 antibody, and may represent a useful diagnostic aid in patients with muscle weakness.

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Accession: 001850130

Download citation: RISBibTeXText

PMID: 2687988

DOI: 10.1016/0167-5699(89)90029-7


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