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Hepatotoxic effect of mebendazole in dogs: clinical, histological and ultrastructural findings following anthelminitc therapy

Hepatotoxic effect of mebendazole in dogs: clinical, histological and ultrastructural findings following anthelminitc therapy

Acta Medica Veterinaria 34(1): 47-57

Five dogs which had received treatment for 3-5 days with mebendazole showed signs including depression, icterus, dysorexia and vomiting. One dog, which had received the largest dose (33 mg/kg) for five days, died; PM examination showed hepatic necrosis and electron microscopy showed severe mitochondrial changes.

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