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In vitro activity of itraconazole (R-51211) against Paracoccidioides brasiliensis, Histoplasma capsulatum var. capsulatum and Histoplasma capsulatum var. duboisii



In vitro activity of itraconazole (R-51211) against Paracoccidioides brasiliensis, Histoplasma capsulatum var. capsulatum and Histoplasma capsulatum var. duboisii



Anais Brasileiros de Dermatologia 63(3): 299-302



Itraconazole was tested in vitro against 8 isolates of P. brasiliensis (M and Y forms), 8 of H. capsulatum var. capsulatum (M form) and 2 of H. capsulatum var. duboisii (M form). In Sabouraud broth at pH 7.0 and room temp., min. inhibitory concn were 0.0005-0.031 micro g/ml for P. brasiliensis, 0.001-0.031 micro g/ml for H. capsulatum and 0.001-0.004 micro g/ml for H. duboisii.

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