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Intraintestinal migration to the epithelium of protective, dividing, anti-Trichinella spiralis CD4+ OX22- cells requires MHC class II compatibility


, : Intraintestinal migration to the epithelium of protective, dividing, anti-Trichinella spiralis CD4+ OX22- cells requires MHC class II compatibility. Journal of Immunology 145(3): 1021-1028

The intraintestinal migration of activated T helper cells belonging to the OX8- OX22- and OX8- OX22+ subsets derived from thoracic duct lymph of rats infected with T. spiralis was measured. Cells in S-phase were labelled with 125IUdR or superscript 3H-TdR in vitro and transfused iv. Identical proportions of both helper cell subsets localized in the small intestine but 3 to 4 times as many OX22- cells as OX22+ cells migrated to the intestinal epithelium.

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Accession: 001869008

PMID: 2142708

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