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Intraintestinal migration to the epithelium of protective, dividing, anti-Trichinella spiralis CD4+ OX22- cells requires MHC class II compatibility


, : Intraintestinal migration to the epithelium of protective, dividing, anti-Trichinella spiralis CD4+ OX22- cells requires MHC class II compatibility. Journal of Immunology 145(3): 1021-1028

The intraintestinal migration of activated T helper cells belonging to the OX8- OX22- and OX8- OX22+ subsets derived from thoracic duct lymph of rats infected with T. spiralis was measured. Cells in S-phase were labelled with 125IUdR or superscript 3H-TdR in vitro and transfused iv. Identical proportions of both helper cell subsets localized in the small intestine but 3 to 4 times as many OX22- cells as OX22+ cells migrated to the intestinal epithelium.

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Accession: 001869008

PMID: 2142708

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Wang C.H.; Korenaga M.; Sacuto F.R.; Ahmad A.; Bell R.G., 1990: Intraintestinal migration to the epithelium of protective dividing anti trichinella spiralis cd4 positive ox22 negative cells requires mhc class ii compatibility. We have measured the intraintestinal migration of activated Th cells belonging to the OX8- OX22- and OX8- OX22+ subsets derived from thoracic duct lymph of rats infected with Trichinella spiralis. Cells in S-phase were labeled with 125I-UdR or 3H-...

Ramaswamy, K.; Goodman, R., E.; Bell, R., G., 1994: Cytokine profile of protective anti-Trichinella spiralis CD4+ OX22- and non-protective CD4+ and OX22+ thoracic duct cells in rats: Secretion of IL-4 alone does not determine protective capacity. We analysed the cytokine profile of a T cell subset (CD4+ CD45 RC-) that confers protection against Trichinella spiralis infection in rats. These CD4+ cells are generated in the gut and appear in the thoracic duct lymph within 72 h after infection...

Ramaswamy, K.; Goodman, R.E.; Bell, R.G., 1994: Cytokine profile of protective anti-Trichinella spiralis CD4+ OX22- and non-protective CD4+ OX22+ thoracic duct cells in rats: secretion of IL-4 alone does not determine protective capacity. We analysed the cytokine profile of a T cell subset (CD4+ CD45 RC-) that confers protection against Trichinella spiralis infection in rats. These CD4+ cells are generated in the gut and appear in the thoracic duct lymph within 72 h after infection...

Ramaswamy, K.; Goodman, R.E.; Bell, R.G., 1994: Cytokine profile of protective anti-Trichinella spiralis CD4+ OX22- and non-protective CD4+ OX22+ thoracic duct cells in rats: secretion of IL-4 alone does not determine protective capacity. We analysed the cytokine profile of a T cell subset (CD4+ CD45 RC-) that confers protection against Trichinella spiralis infection in rats. These CD4+ cells are generated in the gut and appear in the thoracic duct lymph within 72 h after infection...

Korenaga, M.; Wang, C.H.; Bell, R.G.; Zhu, D.; Ahmad, A., 1989: Intestinal immunity to Trichinella spiralis is a property of OX8- OX22- T-helper cells that are generated in the intestine. The phenotype of T-helper cells conferring protection against T. spiralis was studied using adoptive transfer procedures and T-helper cell subsets isolated by monoclonal antibodies. With these techniques OX8- OX22+ and OX8- OX22- T-helper cell pop...

Korenaga M.; Wang C.H.; Bell R.G.; Zhu D.; Ahmad A., 1989: Intestinal immunity to trichinella spiralis is a property of ox8 negative ox22 negative t helper cells that are generated in the intestine. The phenotype of T-helper cells conferring protection against Trichinella spiralis (Ts) was studied using adoptive transfer procedures and T-helper cell subsets isolated by monoclonal antibodies. With these techniques OX8- OX22+ and OX8- OX22- T-h...

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Grencis, R.K.; Wakelin, D., 1982: Short lived dividing cells mediate adoptive transfer of immunity to trichinella spiralis in mice 1. availability of cells in primary and secondary infections in relation to cellular changes in the mesenteric lymph node. After a primary infection with the parasitic nematode T. spiralis, NIH mice showed a short lived increase in cellularity of the mesenteric lymph node (MLN), which began between days 2-4, peaked at day 8 and had declined by day 12. The majority of...