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Invasion of the guinea pig conjunctiva by Toxoplasma gondii



Invasion of the guinea pig conjunctiva by Toxoplasma gondii



Investigative Ophthalmology & Visual Science 29(12): 1871-1880



T. gondii (RH strain) was inoculated onto guineapig conjunctival epithelium. The tissue was fixed 15 min to 48 h after inoculation and examined by electron microscopy. Guineapigs similarly inoculated were maintained in the laboratory for 2 to 8 weeks and tested for antibody by the Toxoplasma dye test. It was found that parasites invaded both epithelial and goblet cells within 15 min of inoculation. Replication occurred within 4 h of inoculation and took place mainly in epithelial cells.

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Accession: 001869409

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PMID: 3192377



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