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Involvement of feed intake in estrogenized chicks for assay of factors affecting hepatic lipid accumulation

Involvement of feed intake in estrogenized chicks for assay of factors affecting hepatic lipid accumulation

Nutrition reports international 37(5): 933-937

The influence of feed intake in estrogenized chicks as a laboratory model for assay of factors affecting hepatic lipid accumulation was assessed in two experiments. The restriction of feed intake to 80% that in ad libitum-fed chicks was attained by either the restriction of feed given or by free access of feed supplemented with cellulose. The hepatic lipids accumulated during 4-day refeeding period after 2 days starvation were proportionately reduced as the degree of restriction was increased. The regression equation computed between hepatic lipids and the amount of feed received revealed that a decrease of one unit feed intake induced a three-fold change in hepatic lipid accumulation. The equation also indicated that 68.4% of the feed consumed by ad libitum -fed chicks would be regarded as minimum feed intake to obtain net hepatic lipid accumulation in the assay system. A correction procedure is presented by which the effect of differences in feed intake on hepatic lipid accumulation can be eliminated and thereby improve the assay system.

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Accession: 001870358

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