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Is peptide YY trophic to the intestinal epithelium of parenterally fed rats?


, : Is peptide YY trophic to the intestinal epithelium of parenterally fed rats?. Digestion 46 Suppl 2: 177-181

Rats maintained intravenously were infused with peptide tyrosine tyrosine (PYY) 0, 5, 20 or 80 mu g daily for 3 days. After 3 days the rats were given by injection vincristine 1 mg/kg in order to arrest cells entering metaphase and were killed 2 h later. The gastrointestinal tract was removed, weighed and fixed. Samples of small intestine and colon were stained, microdissected and the mean number of metaphases per crypt was estimated.

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Accession: 001871104

PMID: 2124556

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Goodlad, R.A.; Wilson, T.J.; Lenton, W.; Gregory, H.; McCullough, K.G.; Wright, N.A., 1985: Urogastrone-epidermal growth factor is trophic to the intestinal epithelium of parenterally fed rats. The weight of the stomach, small intestine and colon and the mucosal crypt cell production rate of these tissues were significantly decreased after 10 days on an isocaloric TPN diet when compared to orally fed controls. Continuous infusion of reco...

Goodlad R.A.; Ghatei M.A.; Domin J.; Bloom S.R.; Wright N.A., 1990: Is peptide yy trophic to the intestinal epithelium of parentally fed rats. Digestion 46(SUPPL 2): 177-181

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