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Isolation and sequence analysis of cDNA for rat carboxypeptidase E [EC 3.4.17.10], a neuropeptide processing enzyme


, : Isolation and sequence analysis of cDNA for rat carboxypeptidase E [EC 3.4.17.10], a neuropeptide processing enzyme. Molecular Endocrinology 3(4): 666-673

A cDNA encoding full-length rat carboxypeptidase E (CPE) was isolated and sequenced. The nucleotide and amino acid sequences of rat CPE showed substantial homology with the bovine sequences. The bovine and rat nucleotide sequences were homologous within the entire coding region, as well as within several portions of the 3' untranslated region. The predicted amino acid sequence of rat CPE was more than 90% homologous with the bovine enzyme.


Accession: 001871739

PMID: 2725530

DOI: 10.1210/mend-3-4-666

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Related references

Fricker, L.D.; Adelman, J.P.; Douglass, J.; Thompson, R.C.; Von-Strandmann, R.P.; Hutton, J., 1989: Isolation and sequence analysis of complementary dna for rat carboxypeptidase e ec 3.4.17.10 a neuropeptide processing enzyme. Carboxypeptidase E (CPE) is the carboxypeptidase B-like enzyme associated with the biosynthesis of numerous peptide hormones and neurotransmitters. This enzyme has been previously purified to homogeneity from bovine tissues, and cDNA clones (non-f...

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