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Lysis of African trypanosomes by human plasma lipoproteins

Lysis of African trypanosomes by human plasma lipoproteins

Biochemical Society Transactions 15(3): 478-479

superscript 3H-labelled Trypanosoma brucei incubated with human high density lipoproteins (HDL), a trypanocidal factor present in human plasma, released 6-20 times more acid-precipitable radioactivity into the culture medium than did parasites incubated with rabbit HDL or buffer. Fractionation of the human HDL established that the small apolipoprotein (apo) A-rich sub-class were the active cytotoxic particles whilst the larger cholesteryl ester and apo E-rich molecules were non-lytic.

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Accession: 001879109

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DOI: 10.1042/bst0150478

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