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Mutation in the A beta gene of B6.C-H-2bm12 generates unique T-cell recognition sites



Mutation in the A beta gene of B6.C-H-2bm12 generates unique T-cell recognition sites



Immunogenetics 26(6): 375-377



Results of skin grafting and mixed lymphocyte reaction studies in mice were consistent with the ideas that (1) T cells recognise predominantly the tertiary structure of Ia molecules in allogeneic responses, and (2) in bm12 mice, sequences from the E beta are flanked by sequences from the A beta gene, resulting in a different tertiary structure from that of the E molecule in F1 mice, in which E beta is represented in its normal configuration.

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Accession: 001891133

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PMID: 2959620



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