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Neuropsychiatric side effects of mefloquine






New England Journal of Medicine 322(24): 1752-1753

Neuropsychiatric side effects of mefloquine

This letter is from Hoffmann-LaRoche, the manufacturers of mefloquine, in response to an earlier letter in the same journal (ibid., 1989, 321, 1415) describing dizziness, vertigo and dysphoria in 4 of 7 volunteers who took mefloquine (about 15 mg/kg). Registration documents indicate that 24% of patients receiving 750 mg 38% receiving 1000 mg and 96% receiving 1500 mg experience dizziness, and that by splitting the dose the incidence is reduced.


Accession: 001893137

PMID: 2342544

DOI: 10.1056/nejm199006143222416



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Weinke, T.; Trautmann, M.; Held, T.; Weber, G.; Eichenlaub, D.; Fleischer, K.; Kern, W.; Pohle, H.D., 1991: Neuropsychiatric side effects after the use of mefloquine. This study describes neuropsychiatric side effects in patients after treatment with mefloquine. Reactions consisted mainly of seizures, acute psychoses, anxiety neurosis, and major disturbances of sleep-wake rhythm. Side effects occurred after bot...

Sowunmi, A.; Salako, L.A.; Oduola, A.M.J.; Walker, O.; Akindele, J.A.; Ogundahunsi, O.A.T., 1993: Neuropsychiatric side effects of mefloquine in Africans. From February 1989 to August 1991, 303 children in Nigeria aged 0.5 to 12 years and 14 adults aged 22 to 48 years with uncomplicated Plasmodium falciparum malaria were treated with single doses of oral mefloquine, 15 or 25 mg/kg bwt in children an...

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Bygbjerg, I.C.; Rønn, A.M., 1999: Long-lasting neuropsychiatric side-effects following mefloquine prophylaxis. A case after six weeks of initiating and lasting six months. Neuropsychiatric side-effects from mefloquine are well known. When used for prophylaxis, the side-effects have been claimed to be relatively rare, mild and transient, most often arising within two to three weeks, and in patients with a previous hi...

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