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New N-terminal modified proctolin analogues: synthesis and their cardioexcitatory effect on insects






International Journal of Peptide and Protein Research 31(5): 463-467

New N-terminal modified proctolin analogues: synthesis and their cardioexcitatory effect on insects

Five proctolin analogues modified in position 1 of the peptide chain by Cit, Lys, His, Phe(p-NH2) and gamma -Abu were synthesized by a conventional liquid phase method.

Accession: 001893240

DOI: 10.1111/j.1399-3011.1988.tb00904.x

Download PDF Full Text: New N-terminal modified proctolin analogues: synthesis and their cardioexcitatory effect on insects



Related references

Konopinska D.; Rosinski G.; Lesicki A.; Sujak P.; Sobotka W.; Bartosz Bechowski H., 1988: New amino terminal modified proctolin analogues synthesis and their cardioexcitatory effect on insects. Five proctolin analogues modified in position 1 of the peptide chain by Cit (I), Lys (II), His (III), Phe(p-NH2) (IV) and .gamma.-Abu (V) were synthesized by conventional liquid phase method. Biological activity of the obtained peptides was invest...

Kuczer, M.; Rosiński, G.; Lisowski, M.; Picur, B.; Konopiñska, D., 1996: New proctolin analogues modified by D-amino acids in the peptide chain and their high cardioexcitatory effect on Tenebrio molitor. The object of our studies was the synthesis and conformational and biological evaluation of the series of 14 analogues of the insect neuropeptide, proctolin. The analogues were obtained by replacement of the native L-amino acids by their D-isomers...

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Konopinska D.; Sobotka W.; Lesicki A.; Rosinski G.; Sujak P., 1986: Synthesis of proctolin analogues and their cardioexcitatory effect on cockroach periplaneta americana and yellow mealworm tenebrio molitor. Five proctolin analogues modified in position 2 of the peptide chain by (4-NH2)- (I), (4-NO2)- (II), (4-NMe2)- (III), (4-OMe)-L-phenylalanine (IV) and .beta.-(cyclohexyl-4-OMe)-L-alanine (V) were synthesized by conventional liquid phase method. Bi...

Konopinska, D.; Rosinski, G.; Bartosz Bechowski, H.; Lesicki, A.; Sujak, P.; Sobotka, W., 1990: Role of guanidine group at the N-terminal proctolin chain in cardioexcitatory effects in insects. Six proctolin analogues (I-VI) modified in position 1 of the peptide chain by the following amino acids: homo-Arg, Gac, Gav, Gap, Phe (p-guanidino) and Orn, were synthesized by conventional liquid phase method. The myotropic activity of the obtain...

Konopińska, D.; Rosiński, G.; Bartosz-Bechowski, H.; Lesicki, A.; Sujak, P.; Sobótka, W., 1990: Role of guanidine group at the N-terminal proctolin chain in cardioexcitatory effects in insects. Six proctolin analogues (I-VI) modified in position 1 of the peptide chain by the following amino acids: homo-Arg, Gac, Gav, Gap, Phe (p-guanidino) and Orn, were synthesized by conventional liquid phase method. The myotropic activity of the obtain...

Konopinska D.; Rosinski G.; Bartosz Bechowski H.; Lesicki A.; Sujak P.; Sobotka W., 1990: Role of guanidine group at the amino terminal proctolin chain in cardioexcitatory effects in insects. Six proctolin analogues (I-VI) modified in position 1 of the peptide chain by the following amino acids: homo-Arg, Gac, Gav, Gap, Phe (p-guanidino) and Orn, were synthesized by conventional liquid phase method. The myotropic activity of the obtain...

Szeszel-Fedorowicz, W.; Rosiński, G.; Issberner, J.; Osborne, R.; Sliwowska, J.; Konopińska, D., 2002: Myotropic effects of new proctolin analogues modified in the position 5 of peptide chain in insects. To explain the role of the Thr5 residue of proctolin (Arg-Tyr-Leu-Pro-Thr) in the myotropic activity of this insect neuropeptide, we synthesized two groups of its analogues: 1) Arg-Tyr-Leu-Pro-X-OH with X = Val (1), D-Val (2), Ile (3), D-Ile (4),...

Kuczer, M.; Rosinski, G.; Issberner, J.; Osborne, R.; Konopinska, D., 1998: New proctolin analogues: Synthesis and biological investigation in insects. We have extended our work on structure/activity relationship studies of the neuropeptiden proctolin (H-ArgTyr-Leu-Pro-Thr-OH) by evaluating the effects of the following proctolin analogues: H-X1-Tyr-Leu-Pro-Thr-OH, where X1 = D-Arg (I), N-Me-Arg (...

Konopinska D.; Bartosz Bechowski H.; Rosinski G.; Lesicki A.; Sujak P.; Sobotka W., 1988: Proctolin analogues synthesis and their influence on heartbeat frequency of insects. Penke, B And A Torok (Ed ) Peptides: Chemistry, Biology, Interactions With Proteins; 50th Anniversary Symposium Of The Nobel Prize Of Albert Szent-Gyorgyi, Szeged, Hungary, August 31-September 4, 1987 Xix+465p Walter De Gruyter And Co : Berlin, West Germany; Hawthorne, New York, Usa Illus 225-228